Classic Hodgkin lymphoma and Castleman disease: an entity appears to be emerging

Virchows Archiv : an International Journal of Pathology
Kirill A LyapichevL Jeffrey Medeiros

Abstract

Hodgkin lymphoma is a B cell neoplasm characterized by Hodgkin and Reed-Sternberg (HRS) cells in an inflammatory background. Classic Hodgkin lymphoma (CHL) accounts for approximately 90% of all cases of HL and four types are recognized in the World Health Organization (WHO) classification: lymphocyte-rich, nodular sclerosis, mixed cellularity, and lymphocyte depleted. Castleman disease (CD) is a designation used for a heterogeneous group of diseases that involve lymph nodes. Histologically, there are hyaline vascular and plasma cell variants, the latter including human herpes virus 8 (HHV8)-positive and HHV8-negative subsets. In this study, we describe three men, 45-57 years of age, one HIV-positive, who had coexistent CHL and CD. All patients had the interfollicular variant of CHL and HHV8-negative plasma cell variant CD. Immunohistochemical analysis supported the diagnosis of CHL; the HRS cells were positive for CD15, CD30, and PAX-5 (dim). In two cases, the HRS cells and the plasma cells of CD expressed interleukin-6 (IL-6). Our review of the literature identified 34 cases of coexistent CHL and CD reported previously. In aggregate, about two-thirds of all cases of CHL have been the interfollicular variant and around 90% of C...Continue Reading

References

Mar 1, 1983·The American Journal of Surgical Pathology·R S DoggettR F Dorfman
Mar 24, 1999·Annals of Hematology·P SalettiF Cavalli
Feb 24, 2001·The Ceylon Medical Journal·S J Hewavisenthi, A N Wedysinghe
Feb 9, 2002·American Journal of Hematology·Claire LarrocheMartine Raphael
Jul 1, 1956·Cancer·B CASTLEMANV P MENENDEZ
Jan 25, 2006·Histopathology·U ZanettoC Pérez
Apr 1, 2009·Indian Journal of Medical and Paediatric Oncology : Official Journal of Indian Society of Medical & Paediatric Oncology·Saadiya Haque, Robert van Kirk
Oct 22, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Preethi Reddy MarriStephen M Ansell
Aug 15, 2014·Leukemia & Lymphoma·Nikhil MunshiJessica Vermeulen
Oct 22, 2014·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Suganya K ReddyDebdatta Basu
Feb 16, 2017·Case Reports in Hematology·L Filliatre-ClementA Perrot
Nov 22, 2017·Hematology/oncology Clinics of North America·David C Fajgenbaum, Dustin Shilling
Nov 22, 2017·Hematology/oncology Clinics of North America·Kazuyuki YoshizakiTomohiro Koga
Mar 24, 2018·Annals of Diagnostic Pathology·Badr AbdullGaffar, Rania M Seliem
Jul 30, 2019·Surgical Pathology Clinics·Wei Wang, L Jeffrey Medeiros

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