Classic Papers Revisited: My Love Affair with the Venous System

Anesthesiology
Simon Gelman

Abstract

The Pathophysiology of Aortic Cross-clamping and Unclamping. By Gelman S. ANESTHESIOLOGY 1995; 82:1026-60. Reprinted with permission.Aortic cross-clamping (AoX) and unclamping are associated with severe hemodynamic disturbances in virtually all organs and systems. The main hemodynamic changes induced by AoX result from an increase in impedance to aortic flow, an increase in systemic vascular resistance and afterload, blood volume redistribution caused by collapse and constriction of venous vasculature distal to the aortic clamp, and a subsequent increase in preload. Preload may not increase if the aorta is clamped distal to the celiac artery; in that case, blood volume from distal venous vasculature may be redistributed to the splanchnic vasculature without associated increases in preload. Increases in afterload and preload demand an increase in contractility, which results in an autoregulatory increase in coronary blood flow. Without increases in coronary blood flow and myocardial contractility, decompensation may occur. Aortic cross-clamping is associated with the formation and release of many mediators which constitute a double-edged sword: they may mitigate or aggravate the harmful hemodynamic effects of AoX and unclamping....Continue Reading

References

Apr 1, 1988·American Journal of Surgery·S GelmanJ Proctor
Dec 1, 1984·Archives of Surgery·S GelmanL R Smith
Feb 1, 1994·Anesthesia and Analgesia·S GelmanT Henderson
Dec 20, 2017·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Simon Gelman, Luca Bigatello

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Citations

Dec 5, 2020·European Journal of Anaesthesiology·Simon Gelman

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