PMID: 43515Nov 1, 1979

"Classical" and "atypical" antipsychotic drugs: differential antagonism of amphetamine- and apomorphine-induced alterations of spontaneous neuronal activity in the neostriatum and nucleus accumbens

Pharmacology, Biochemistry, and Behavior
G V RebecK D Alloway

Abstract

The ability of clozapine and haloperidol to antagonize the depression of firing rate produced by d-amphetamine and apomorphine in the neostriatum and nucleus accumbens was tested in immobilized, locally anesthetized rats. In the neostriatum, an intraperitoneal injection of 2.5 mg/kg d-amphetamine or 1.0 mg/kg apomorphine produced a prolonged inhibition of neuronal activity that was reversed by a subjsequent injection of either 20 mg/kg clozapine or 2.0 mg/kg haloperidol. An analysis of the onset and magnitude of the blockade revealed that clozapine was more effective than haloperidol in reversing the amphetamine response but that both antipsychotic drugs produced a comparable blockade of the apomorphine-induced depression. Similar results were obtained in the nucleus accumbens. The data indicate that although clozapine acts equieffectively in the neostriatum and nucleus accumbens, this atypical antipsychotic drug, aside from blocking postsynaptic dopamine receptors, may exert at least some of its effects by preventing dopamine release.

References

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Citations

Jan 10, 1989·European Journal of Pharmacology·H E CriswellGeorge R Breese
Mar 1, 1980·Neuropharmacology·G V RebecK D Alloway
Aug 1, 1983·Pharmacology, Biochemistry, and Behavior·G V Rebec, E H Lee
Jun 1, 1986·Pharmacology, Biochemistry, and Behavior·G D Anderson, G V Rebec
Jan 1, 1983·Progress in Neuro-psychopharmacology & Biological Psychiatry·P L WoodN P Nair
Sep 1, 1983·Brain Research Bulletin·S L Hartgraves, P H Kelly
Jul 15, 1998·Neuroscience and Biobehavioral Reviews·J L HaraczG V Rebec
Jan 1, 1990·Annals of the New York Academy of Sciences·H Y Meltzer
Jan 1, 1993·Neuroscience and Biobehavioral Reviews·J L HaraczG V Rebec
Jun 26, 2004·The European Journal of Neuroscience·Mustapha BennayMichael Koch
Jan 1, 1990·Neuroscience and Biobehavioral Reviews·J BruhwylerM Mercier

Related Concepts

Mydrial
Metazoa
Apokinon
Brain
Caudate Nucleus Structure
Electric Stimulation Technique
Electroencephalogram
Neurons
Nucleus Accumbens
Structure of Putamen

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