PMID: 9525860Apr 29, 1998Paper

Classical conditioning and brain systems: the role of awareness

Science
R E Clark, L R Squire

Abstract

Classical conditioning of the eye-blink response, perhaps the best studied example of associative learning in vertebrates, is relatively automatic and reflexive, and with the standard procedure (simple delay conditioning), it is intact in animals with hippocampal lesions. In delay conditioning, a tone [the conditioned stimulus (CS)] is presented just before an air puff to the eye [the unconditioned stimulus (US)]. The US is then presented, and the two stimuli coterminate. In trace conditioning, a variant of the standard paradigm, a short interval (500 to 1000 ms) is interposed between the offset of the CS and the onset of the US. Animals with hippocampal lesions fail to acquire trace conditioning. Amnesic patients with damage to the hippocampal formation and normal volunteers were tested on two versions of delay conditioning and two versions of trace conditioning and then assessed for the extent to which they became aware of the temporal relationship between the CS and the US. Amnesic patients acquired delay conditioning at a normal rate but failed to acquire trace conditioning. For normal volunteers, awareness was unrelated to successful delay conditioning but was a prerequisite for successful trace conditioning. Trace conditi...Continue Reading

References

Jan 1, 1990·Journal of Clinical and Experimental Neuropsychology·D L Schacter
Jan 1, 1973·Psychophysiology·D A Grant
May 1, 1973·Journal of Experimental Psychology·M E Dawson, P Reardon
Jan 1, 1994·Annual Review of Neuroscience·R F Thompson, D J Krupa
Jan 1, 1993·Annual Review of Neuroscience·D L SchacterK N Ochsner
Jan 1, 1997·Annual Review of Psychology·H Eichenbaum
Nov 1, 1959·Journal of Experimental Psychology·K W SPENCE, L E ROSS

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Citations

Dec 8, 2010·Archives of General Psychiatry·Christine KonradiStephan Heckers
Jan 9, 1999·Hippocampus·K S LaBar, J F Disterhoft
Dec 26, 2001·The Anatomical Record·B G Schreurs, D L Alkon
Nov 14, 2002·Developmental Psychobiology·Dragana I ClaflinDragana I Klaflin
May 2, 2003·Hippocampus·Adam Z Weitemier, Andrey E Ryabinin
Jan 29, 2002·Hippocampus·J R Manns, L R Squire
Aug 21, 2002·Integrative Physiological and Behavioral Science : the Official Journal of the Pavlovian Society·Catherine E MyerMark A Gluck
Oct 23, 2001·Integrative Physiological and Behavioral Science : the Official Journal of the Pavlovian Society·D S Woodruff-Pak
Jan 5, 2002·Integrative Physiological and Behavioral Science : the Official Journal of the Pavlovian Society·J E SteinmetzJ T Green
Feb 24, 2006·Integrative Physiological and Behavioral Science : the Official Journal of the Pavlovian Society·Jo Anne TracyJoseph E Steinmetz
Dec 17, 2008·Neurotoxicity Research·José M Delgado-García, Agnès Gruart
Jun 8, 2006·Psychopharmacology·Catherine M Brignell, H Valerie Curran
Dec 25, 2010·Psychopharmacology·Sonja RömerHartmut Schächinger
Dec 6, 2005·Experimental Brain Research·M GerwigD Timmann
Mar 21, 2012·Experimental Brain Research·Cigdem Onal-HartmannJoseph Classen
Sep 6, 2012·Experimental Brain Research·Marja LaasonenJan Wikgren
Aug 7, 2009·Animal Cognition·Janicke NordgreenTor Einar Horsberg
Aug 18, 2006·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Ramesh K Khurana
Oct 23, 2009·Journal of Computational Neuroscience·François RivestYoshua Bengio
May 5, 2011·Neuropsychology Review·Sandra W JacobsonChristopher D Molteno
Sep 29, 2009·Neuroscience Bulletin·Zhao-Hui Xu, Ming-Gao Zhao
May 5, 2005·Physiology & Behavior·Dragana Ivkovich ClaflinSarah J Jensen
Mar 9, 1999·Life Sciences·J F DisterhoftC Weiss
Apr 5, 2002·Neuropsychologia·Stephan HamannFelicia C Goldstein
Oct 24, 2003·Neuropsychologia·Catherine E MyersNarinder Kapur
Mar 18, 1999·Pharmacology, Biochemistry, and Behavior·M M GhoneimR I Block
Dec 14, 1999·Neuroscience and Biobehavioral Reviews·D A Powell
Dec 2, 1999·Neuroscience and Biobehavioral Reviews·A TobenaR Dar
Dec 22, 1998·Brain Research. Brain Research Reviews·K C Berridge, T E Robinson
Feb 19, 2002·Journal of Neuroscience Methods·Edwin D Ayers, D A Powell
May 10, 2000·Behavioural Brain Research·T J ShorsE Gould
Oct 6, 2001·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·H Shevrin

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