Classical dopamine agonists

Journal of Neural Transmission
R Horowski, P-A Löschmann

Abstract

The pioneering work of Arvid Carlsson has laid the foundation for a number of innovative therapies for severe central nervous system (CNS) diseases. He was awarded the Nobel Price for the discovery of the crucial role of dopamine (DA) as a neurotransmitter in the CNS, thereby forming the basis for the symptomatic therapy of Parkinson's disease (PD) with L-DOPA and subsequently dopaminergic drugs. Parenteral apomorphine has a short lasting effect in PD, bromocriptine can be administered orally and has a long-lasting effects but is poorly tolerated. Lisuride on the other hand has a high affinity to DA receptors and can be administered orally, parenterally or via the transdermal route of administration. Last but not least Carlsson developed the concepts of presynaptic effects of DA agonists as well as DA partial agonism potentially innovative mechanisms for treatment of PD and schizophrenia.

References

Feb 1, 1978·The Journal of Clinical Endocrinology and Metabolism·A LiuzziR Horowski
Apr 1, 1978·Archiv der Pharmazie·K RehseR Horowski
Apr 1, 1976·European Journal of Pharmacology·R Horowski, H Wachtel
Jan 1, 1992·Clinical Neuropharmacology·P A LöschmannH Wachtel
May 13, 1989·BMJ : British Medical Journal·A HerzogR Ziegler
Jan 1, 1988·Journal of Neural Transmission. Supplementum·R HorowskiJ A Obeso
Jan 1, 1988·Psychopharmacology·D M JacksonS B Ross
Sep 12, 1985·The New England Journal of Medicine·A LiuzziG Luccarelli
Sep 1, 1967·The Journal of Pharmacy and Pharmacology·N E AndénT Hökfelt
Nov 23, 1974·British Medical Journal·D B CalneA Petrie
Nov 15, 1968·Experientia·E Flückiger, H R Wagner
Jul 1, 1984·Circulation Research·W J MarvinK Hermsmeyer
Jan 1, 1983·European Neurology·R J McDonald, R Horowski
Aug 17, 2002·Brain : a Journal of Neurology·Fabrizio StocchiC Warren Olanow
Sep 4, 2004·Seminars in Liver Disease·Stefano Brillanti
May 16, 2009·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Fabrizio Stocchi

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