Classical twin design in modern pharmacogenomics studies

Pharmacogenomics
Nilüfer Rahmioğlu, Kourosh R Ahmadi

Abstract

Response to medication is highly variable, unpredictable and, at times, may be fatal. All drugs are more effective in certain groups of the population while showing no or minimal benefit in other groups. Although the current data on the subject are piecemeal, anecdotal evidence suggests that, in line with other common multifactorial traits, a myriad of genomic as well as environmental factors underpin population variability in drug response. Pharmacogenomics is the study of how variations in the human genome affect the variability in response to medication. Efforts to personalize treatment based on results from pharmacogenomics studies have the potential to increase efficacy, lower the overall cost of treatment, and decrease the incidence of adverse drug reactions, and are one of the major challenges of the modern era. The classical twin design has traditionally been used to assess the relative contribution of genetic and environmental factors to population variation in common, complex phenotypes, including drug response. Twins are not commonly regarded as providing the optimal design in genomic studies. However, we argue that, through their precise 'matching' for confounding variables (age, sex, cohort and common environmental...Continue Reading

References

Jan 1, 1978·Reviews of Physiology, Biochemistry and Pharmacology·P Propping
Nov 1, 1979·Clinical Pharmacokinetics·W W Weber, D W Hein
Jul 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·K P VatsisW W Weber
Jan 1, 1989·Pharmacology & Therapeutics·E S Vesell
Jan 1, 1969·Annual Review of Medicine·P Armitage
Jul 31, 1968·Annals of the New York Academy of Sciences·D A Evans
Dec 1, 1969·The Journal of Clinical Investigation·E S Vesell, J G Page
Dec 1, 1981·Environmental Health Perspectives·J C Christian
Jul 1, 1994·Behavior Genetics·D L Duffy
May 1, 1997·Nature·A P Wolffe
Dec 17, 1997·Nature Genetics·N MartinG Machin
Jul 29, 1998·The Annals of Pharmacotherapy·E L MichaletsE D Van Tassel
Oct 3, 1998·American Journal of Human Genetics·D B AllisonN J Schork
Feb 26, 2000·Trends in Genetics : TIG·A J MacGregorT D Spector
Feb 7, 2001·BMJ : British Medical Journal·C R WolfR L Smith
May 29, 2000·Clinical Pharmacology and Therapeutics·C A RobyA H Burstein
Jun 15, 2000·The New England Journal of Medicine·C J HammondC E Gilbert
Jun 19, 2001·American Journal of Human Genetics·J K Pritchard
Aug 30, 2001·Trends in Genetics : TIG·D E Reich, E S Lander
Nov 5, 2002·Nature Reviews. Genetics·Dorret BoomsmaLeena Peltonen
Feb 25, 2003·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M J MillwardJ F Bishop
Mar 11, 2004·Journal of Thrombosis and Haemostasis : JTH·A Blann, D Bareford
Sep 11, 2004·American Journal of Human Genetics·Candace R Correa, Vivian G Cheung
Oct 28, 2004·Nature Genetics·Sarah K Tate, David B Goldstein
Nov 6, 2004·Twin Research : the Official Journal of the International Society for Twin Studies·Gary E SwanMichelle Wambach
Mar 2, 2005·Nature Reviews. Genetics·Abdallah S Daar, Peter A Singer
Jul 13, 2005·Proceedings of the National Academy of Sciences of the United States of America·Mario F FragaManel Esteller
Aug 4, 2005·Science's STKE : Signal Transduction Knowledge Environment·Eric E SchadtStephen Friend
Nov 1, 2005·Drug Metabolism Reviews·Sotiria Boukouvala, Giannoulis Fakis
Apr 19, 2006·Nature Reviews. Genetics·Nan M Laird, Christoph Lange
Jun 8, 2006·European Journal of Clinical Pharmacology·Nael Al KoudsiRachel F Tyndale
Feb 15, 2007·The FEBS Journal·John C LindonJeremy K Nicholson

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Citations

Jul 14, 2011·Pharmacogenetics and Genomics·Nilufer RahmiogluKourosh R Ahmadi
Apr 3, 2012·Pain·Christopher Sivert Nielsen
Mar 27, 2012·Pain·Martin S AngstDavid J Clark
May 22, 2013·PloS One·Ana Isabel AntonRocio Gonzalez-Conejero
Mar 1, 2012·Journal of Clinical Psychopharmacology·Jose de Leon
Oct 12, 2016·Current Protocols in Human Genetics·Jacob B Hall, William S Bush
Jun 21, 2012·Anesthesiology·Martin S AngstJ David Clark
Aug 15, 2018·Neuropsychopharmacology Reports·Kaori YoshidaKazutaka Ikeda
May 11, 2018·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Veronika V OdintsovaDorret I Boomsma
May 29, 2021·Schizophrenia Research·Amanda J LisowayJames L Kennedy
May 26, 2011·Current Opinion in Pediatrics

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Methods Mentioned

BETA
acetylation
histone acetylation

Software Mentioned

PGx
Mx

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