Classics in Neuroimaging: Development of PET Tracers for Imaging Monoamine Oxidases

ACS Chemical Neuroscience
Vidya NarayanaswamiNeil Vasdev

Abstract

In this Viewpoint, we highlight the history of positron emission tomography (PET) radiotracer development to quantify changes in monoamine oxidase (MAO)-A and -B enzyme expression or activity. MAO-A and MAO-B are critical for understanding monoaminergic pathways in psychiatric addiction disorders, and more recently in neurodegenerative disorders with MAO-B expression in astrogliosis. Unique radiochemical innovations have been shown for neuroimaging of MAOs including the clinical translation of irreversible propargylamine-based suicide inhibitors, application of deuterium-substitution to slow down metabolism, development of trapped metabolite imaging agents, and unique 11C-carbonylation chemistry toward novel high-affinity reversibly binding inhibitors.

References

Jan 4, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Stephen F CarterAgneta Nordberg

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Citations

Sep 10, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Santosh Reddy AlluriKun-Eek Kil
Nov 7, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dong WangDe-Xin Kong
Apr 4, 2021·Antioxidants·Eduardo Felipe Alves Fernandes, Dennis Özcelik
Jul 11, 2020·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Ryuichi HaradaNobuyuki Okamura
Nov 21, 2020·ACS Medicinal Chemistry Letters·Allen F BrooksPeter J H Scott
Aug 14, 2020·Journal of Chemical Information and Modeling·N Arul Murugan, Robert Zaleśny
Jul 25, 2019·ACS Chemical Neuroscience·Lindsey R DrakePeter J H Scott
Dec 8, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Yu LiuHong Zhang
Jan 21, 2022·ACS Chemical Neuroscience·Ryuichi HaradaShozo Furumoto

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