Classics in Neuroimaging: The Serotonergic 2A Receptor System-from Discovery to Modern Molecular Imaging

ACS Chemical Neuroscience
Elina T L'EstradeMatthias M Herth

Abstract

Already in 1953, Woolley and Shaw speculated that serotonin could be involved in a range of central nervous system (CNS) disorders. Lysergic acid diethylamide (LSD) displayed an important role in this respect. It was used not only to antagonize biological effects of serotonin and to study the system itself, but also to identify serotonergic subtype receptors. The 5-HT2A receptor was discovered in the 1970s and identified as the responsible receptor mediating psychedelic effects of LSD. The development of positron emission tomography (PET) allowed to study this receptor system in vivo. Parameters such as abundance of 5-HT2A neuroreceptors or receptor occupancy can be determined using PET. As such, the development of 5-HT2A receptor tracers started immediately after the introduction of PET in the mid-1970s. In this Viewpoint, we provide a historical overview from the discovery of serotonin to the identification of the 5-HT2A receptor subtype and the subsequent development of 5-HT2A receptor subtype specific PET tracers over the last four decades. We emphasize the interplay between pharmacology, medicinal chemistry, radiochemistry, and nuclear medicine that is important while developing a PET tracer. Moreover, we highlight selecte...Continue Reading

References

Jul 29, 2010·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Louise M PatersonGitte M Knudsen
May 23, 2015·Journal of Labelled Compounds & Radiopharmaceuticals·Matthias M Herth, Gitte M Knudsen

❮ Previous
Next ❯

Citations

Nov 23, 2019·BMC Veterinary Research·Glenn PauwelynFilip De Vos
Sep 18, 2021·Journal of Neurochemistry·Natasha S R BidesiMatthias M Herth

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antiparasitics

Antiparasitics are medications which are indicated for the treatment of parasitic diseases. Discover the latest research on antiparasitics here.

Related Papers

Comptes rendus des séances de la Société de biologie et de ses filiales
P CHAUCHARD, H MAZOUE
Journal of Labelled Compounds & Radiopharmaceuticals
Matthias M Herth, Gitte M Knudsen
© 2022 Meta ULC. All rights reserved