Classification and grading of low-grade astrocytic tumors in children.

Brain Pathology
C Giannini, B Scheithauer

Abstract

This article reviews current perspectives in the classification and grading of astrocytomas in children and calls attention to several histologically distinct groups of low-grade tumors that characteristically arise during childhood. Recognition of these tumors and the range of histological features that they may exhibit is essential for making rational assessments regarding their expected behavior and, more importantly, for guiding therapeutic intervention. For example, pleomorphic xanthoastrocytoma, which may exhibit "anaplastic" features, generally carries a relatively favorable prognosis and should not be classified with other high-grade gliomas, such as anaplastic astrocytoma and glioblastoma multiforme. Similarly, the finding of anaplastic features, such as vascular proliferation or necrosis, in pilocytic astrocytomas does not automatically portend the unfavorable prognosis that such features would imply for "diffuse" astrocytomas. Increased appreciation of the morphological diversity of astrocytomas in children should help to improve the management of children with low-grade astrocytic tumors by avoiding potentially dangerous overtreatment of otherwise indolent lesions.

References

Jul 1, 1979·Cancer·T W GriffinJ C Blasko
Jul 1, 1978·Journal of Neurosurgery·G M KleinmanE P Richardson
Aug 1, 1978·Journal of Neurosurgery·F Gjerris, L Klinken
Apr 1, 1976·Neurology·W B WilsonS L Nielsen
Jan 11, 1992·Neurosurgery·J H SchneiderJ G McComb
Jan 1, 1991·Neurosurgical Review·M Lange, W Feiden
Sep 1, 1991·Cancer Genetics and Cytogenetics·J R SawyerF A Boop
Jan 1, 1991·Journal of Neurosurgery·T S KimK Convery
Nov 1, 1990·Journal of Neurosurgery·J H WisoffF Epstein
May 1, 1990·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·N MorotaK Hashimoto
Jan 15, 1990·Cancer·A M Schwartz, N R Ghatak
Mar 1, 1989·Journal of Neurosurgery·I R WhittleA J Steers
Nov 1, 1989·Journal of Neurosurgery·D M GarciaS Picker
Sep 1, 1987·Annals of Neurology·E J DropchoJ C Allen
Aug 1, 1988·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·S J GaskillV Saldivar
Nov 29, 1986·Lancet·J M ConnorM D Hadley
Nov 15, 1988·Cancer·C Daumas-DuportP Kelly
Feb 15, 1988·Cancer·J C FlickingerM Deutsch
Aug 1, 1988·Journal of Neurosurgery·K E WallnerG E Sheline
Dec 1, 1986·Journal of Neurosurgery·A L AlbrightL B Rourke
Feb 1, 1985·Journal of Neurosurgery·C RaffelA R Ablin
Jan 1, 1985·Journal of Neurosurgery·G K SteinbergJ W Hanbery
May 1, 1985·The British Journal of Radiology·M L Maat-SchiemanG J Vielvoye
Jan 1, 1985·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·M KanamoriN Kageyama
Feb 19, 1973·Acta Neuropathologica·J J KepesF Slowik

❮ Previous
Next ❯

Citations

Feb 12, 1999·Cancer Genetics and Cytogenetics·M Debiec-RychterP P Liberski
May 15, 2002·International Journal of Radiation Oncology, Biology, Physics·Frank H SaranMichael Brada
Aug 10, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sandrine RoriveIsabelle Salmon
Apr 3, 2012·Journal of Biomedical Optics·Dennis WirthAnna N Yaroslavsky
May 29, 2007·Neuroradiology·Sylvie D GrandJean François Le Bas
Nov 7, 2006·Journal of Neuropathology and Experimental Neurology·David T W JonesV Peter Collins
Aug 10, 2006·Journal of Neuropathology and Experimental Neurology·Sandrine RoriveChristine Decaestecker
Apr 14, 2012·Brain Pathology·Maria ThomEleonora Aronica
Oct 12, 2012·Brain Pathology·Marina Paola GardimanGiorgio Perilongo
Apr 6, 2004·Pediatric Clinics of North America·Cormac O Maher, Corey Raffel
Aug 17, 1999·Seminars in Cancer Biology·V P Collins
Nov 26, 2011·Dento Maxillo Facial Radiology·S G DuaT Shet
Oct 5, 2016·The Journal of Pathology·Jason Ch Chiang, David W Ellison
Sep 2, 2003·Veterinary Pathology·S SisóM Pumarola
Jul 1, 2006·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Minzhi YinChung Wo Chow
Jul 23, 2009·The American Journal of Surgical Pathology·Jason L HornickChristopher D M Fletcher
May 8, 2020·Cancers·Kelly L Collins, Ian F Pollack
Apr 10, 2014·Journal of Pediatric Hematology/oncology·Sunil S RaikarKaren M Gauvain

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.