Classification of alcoholics on the basis of plasma beta-endorphin concentration

Alcohol
J C AguirreM T Miranda

Abstract

Recent findings suggest that a genetic deficit in opioid may be a biological marker of alcoholism. In other words, decreased plasma concentrations of opioids may be a predisposing factor, rather than a consequence, of alcohol consumption. We attempted to classify 88 randomly chosen individuals as alcoholics or nonalcoholics on the basis of plasma concentration of beta-endorphins. This criterion had a sensitivity of 73.30% and a specificity of 79.45%. Its positive predictive value was 42.30%, and its negative predictive value was 93.55%.

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Jul 8, 2008·Psychopharmacology·Judith E GriselVictoria L Turgeon
Jan 1, 1996·Peptides·G A OlsonA J Kastin
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May 20, 2015·British Journal of Pharmacology·Florence NobleNicolas Marie

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