Classification of antiarrhythmic drugs based on ventricular fibrillation threshold.

The American Journal of Cardiology
K HarumiS Sekiya

Abstract

The antifibrillatory action of antiarrhythmic drugs, classified on the basis of their effects on ventricular fibrillation threshold (VFT), was investigated. The relation between drug action and cardiac excitability, orthodromic/antidromic conduction through Purkinje fibers and ventricular muscle and the restitution of premature action potential duration was studied. Drug classifications were: group A, VFT markedly increased; group B, VFT moderately increased; and group C, no significant change. Group A was subdivided according to presence or absence of the dip phenomenon and supernormal period in the anodal strength-interval curve. Drugs in group A significantly reduced the difference between effective refractory period of orthodromic and antidromic conduction and the range over which the premature action potential duration reappeared. In groups B and C, the effective refractory period in orthodromic conduction was longer than that in controls, and the range of the restitution of premature action potential duration for Purkinje fibers was reduced only slightly.

References

Dec 1, 1977·American Heart Journal·C J LyonsJ A Abildskov

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Citations

Jan 1, 1997·Progress in Biophysics and Molecular Biology·D Wei
Feb 25, 1998·Journal of Cardiovascular Electrophysiology·R D MitraniD P Zipes
Mar 3, 2009·Journal of Electrocardiology·Elena Ryzhii, Daming Wei
Feb 10, 1998·Pacing and Clinical Electrophysiology : PACE·C D MazerP Dorian
Dec 19, 2001·American Journal of Physiology. Heart and Circulatory Physiology·Tetsu WatanabeHitonobu Tomoike

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