Classification of autistic individuals and controls using cross-task characterization of fMRI activity

NeuroImage. Clinical
Guillaume ChanelJulie Grèzes

Abstract

Multivariate pattern analysis (MVPA) has been applied successfully to task-based and resting-based fMRI recordings to investigate which neural markers distinguish individuals with autistic spectrum disorders (ASD) from controls. While most studies have focused on brain connectivity during resting state episodes and regions of interest approaches (ROI), a wealth of task-based fMRI datasets have been acquired in these populations in the last decade. This calls for techniques that can leverage information not only from a single dataset, but from several existing datasets that might share some common features and biomarkers. We propose a fully data-driven (voxel-based) approach that we apply to two different fMRI experiments with social stimuli (faces and bodies). The method, based on Support Vector Machines (SVMs) and Recursive Feature Elimination (RFE), is first trained for each experiment independently and each output is then combined to obtain a final classification output. Second, this RFE output is used to determine which voxels are most often selected for classification to generate maps of significant discriminative activity. Finally, to further explore the clinical validity of the approach, we correlate phenotypic informati...Continue Reading

References

Mar 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·K J FristonR Turner
Jun 22, 2000·Trends in Cognitive Sciences·T AllisonG McCarthy
Jul 24, 2002·Brain : a Journal of Neurology·Fulvia CastelliUta Frith
Mar 4, 2003·Nature Reviews. Neuroscience·Martin A Giese, Tomaso Poggio
Aug 21, 2004·Brain : a Journal of Neurology·Karen PierceEric Courchesne
Jan 25, 2005·Mental Retardation and Developmental Disabilities Research Reviews·Kevin PelphreyJames P Morris
Mar 8, 2005·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Robert T Schultz
May 24, 2005·NeuroImage·Stephen LaConteXiaoping Hu
Mar 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Nikolaus KriegeskortePeter Bandettini
May 17, 2006·Proceedings of the National Academy of Sciences of the United States of America·Daniel P KennedyEric Courchesne
Jun 30, 2006·Trends in Neurosciences·Monica ZilboviciusNathalie Boddaert
Feb 3, 2007·NeuroImage·J GrèzesB de Gelder
Jun 8, 2007·Trends in Cognitive Sciences·Sonia J Bishop
Jun 23, 2007·Journal of Cognitive Neuroscience·Chris RordenLeonardo Bonilha
Nov 4, 2008·Social Neuroscience·Swann PichonJulie Grezes
Dec 17, 2008·NeuroImage·Francisco PereiraMatthew Botvinick
Apr 26, 2011·NeuroImage·Marc N CoutancheRobert T Schultz
Jun 15, 2011·Cerebral Cortex·Swann PichonJulie Grèzes
Oct 12, 2011·Journal of Autism and Developmental Disorders·Coralie ChevallierFrancesca Happé
Oct 19, 2011·Brain : a Journal of Neurology·Jeffrey S AndersonJanet E Lainhart
Mar 20, 2012·Trends in Cognitive Sciences·Coralie ChevallierRobert T Schultz
Mar 30, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Laurence ContyJulie Grèzes
Sep 15, 2012·Current Biology : CB·Daniel Nettle, Melissa Bateson
Sep 3, 2013·NeuroImage·Jonathan D PowerSteven E Petersen
Oct 24, 2013·Frontiers in Human Neuroscience·Gopikrishna DeshpandeRajesh K Kana
Jan 15, 2014·Nature Reviews. Neurology·Christine Ecker, Declan Murphy
Jul 6, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·David Pitcher
Jul 9, 2014·Annual Review of Neuroscience·James V HaxbyJ Swaroop Guntupalli
Aug 28, 2014·Frontiers in Psychiatry·Andre A S GoldaniRobert L Hendren
Dec 4, 2014·Trends in Neurosciences·Eric B London

❮ Previous
Next ❯

Citations

May 7, 2020·Human Brain Mapping·Barnaly Rashid, Vince Calhoun
Mar 22, 2019·Frontiers in Neuroinformatics·Mengyue WangRenji Chen
Oct 2, 2020·Translational Psychiatry·Ryan Anthony J de BelenDennis Del Favero
Dec 19, 2018·NeuroImage. Clinical·Stefano DamianiGeorg Northoff
Jun 27, 2021·Journal of Neuroscience Methods·Ming XuJing Sui

❮ Previous
Next ❯

Software Mentioned

MRIcron
SPM8
MVPA
Matlab

Related Concepts

Related Feeds

Autism

Autism spectrum disorder is associated with challenges with social skills, repetitive behaviors, and often accompanied by sensory sensitivities and medical issues. Here is the latest research on autism.

Related Papers

IEEE Transactions on Information Technology in Biomedicine : a Publication of the IEEE Engineering in Medicine and Biology Society
Argyro KampourakiChristophoros Nikou
Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi
Xinmei XuXiaoli Shao
© 2022 Meta ULC. All rights reserved