Classification of brain tumours from MR spectra: the INTERPRET collaboration and its outcomes

NMR in Biomedicine
Margarida Julià-SapéCarles Arús

Abstract

The INTERPRET project was a multicentre European collaboration, carried out from 2000 to 2002, which developed a decision-support system (DSS) for helping neuroradiologists with no experience of MRS to utilize spectroscopic data for the diagnosis and grading of human brain tumours. INTERPRET gathered a large collection of MR spectra of brain tumours and pseudo-tumoural lesions from seven centres. Consensus acquisition protocols, a standard processing pipeline and strict methods for quality control of the aquired data were put in place. Particular emphasis was placed on ensuring the diagnostic certainty of each case, for which all cases were evaluated by a clinical data validation committee. One outcome of the project is a database of 304 fully validated spectra from brain tumours, pseudotumoural lesions and normal brains, along with their associated images and clinical data, which remains available to the scientific and medical community. The second is the INTERPRET DSS, which has continued to be developed and clinically evaluated since the project ended. We also review here the results of the post-INTERPRET period. We evaluate the results of the studies with the INTERPRET database by other consortia or research groups. A summa...Continue Reading

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Citations

Oct 11, 2017·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Sreenath P KyathanahallyRoland Kreis
Jan 12, 2019·NMR in Biomedicine·Margarida Julià-SapéCarles Arús
Oct 27, 2018·Physics in Medicine and Biology·Geoffrey S Payne
Dec 4, 2019·NMR in Biomedicine·Yanisleydis Hernández-VillegasMargarida Julià-Sapé

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