Classification of cysts with follicular germinative differentiation

Journal of Cutaneous Pathology
Juan C H López-TakegamiAlmut Böer-Auer

Abstract

Cysts are very common in the routine of dermatopathology but follicular germinative (trichoblastic) differentiation in cysts is seen rarely. The presence of follicular germinative differentiation in a cyst alerts to consider the possibility of a basal cell carcinoma (BCC) arising in a cyst. Five cystic lesions with zones of follicular germinative differentiation were collected. Hematoxylin and eosin sections were reassessed for architecture, types of follicular differentiation and stromal characteristics; immunohistochemical studies with Ber-EP4 were analyzed. Articles about follicular germinative differentiation in cystic lesions were reviewed. Cystic lesions with follicular germinative differentiation have been described in the literature under various names including trichoblastic infundibular cyst, cystic trichoblastoma, cystic panfolliculoma (CPF), dermoid cyst with basaloid proliferations, folliculosebaceous cystic hamartoma and BCC occurring in infundibular cysts. The lesions presented by us could be classified as three cystic trichoblastomas, one CPF and one cystic hamartoma with follicular germinative differentiation. Histopathologically, cystic trichoblastomas can be separated from CPFs. Some lesions defy classificati...Continue Reading

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Citations

Aug 24, 2016·Journal of Cutaneous Pathology·Brett NeillSusan Zurowski
Apr 8, 2017·Annales de chirurgie plastique et esthétique·M ThomasC Dissaux
Mar 13, 2019·The Journal of Dermatology·Yuuki ShiinaTetsuya Tsuchida
Jul 24, 2020·Dermatologic Therapy·Uwe Wollina, Jacqueline Schönlebe
Jul 13, 2018·Dermatopathology·Gürkan Kaya, Jean-Hilaire Saurat
Oct 22, 2019·The American Journal of Dermatopathology·Noelia Pérez-MuñozMaría-Teresa Fernández-Figueras

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