Classification of Histologic Patterns of Pseudocapsular Invasion in Organ-Confined Renal Cell Carcinoma

Clinical Genitourinary Cancer
Alessandro VolpeCarlo Terrone

Abstract

A standardized histologic definition and classification of the patterns of renal tumor pseudocapsular invasion (RTPI) in renal cell carcinoma (RCC) is not available. We classified RTPI into 2 main histologic patterns: expansive and infiltrative RTPI. Patients with organ-confined RCC and infiltrative RTPI had a greater risk of cancer-specific death and might require stricter postoperative surveillance strategies. A standardized histologic definition and classification of patterns of renal tumor pseudocapsular invasion (RTPI) in renal cell carcinoma (RCC) is not available. The aim of the present study was to propose a classification of RTPI patterns and assess their correlation with other pathologic features and prognosis. The renal tumor pseudocapsule was assessed by 2 expert genitourinary pathologists on the histologic slides of 190 specimens from radical nephrectomy performed for organ-confined (pT1-pT2) RCC. The histologic patterns of RTPI were classified and described. The association between the RTPI patterns and other pathologic features was assessed. The Kaplan-Meier method was used to calculate the survival functions, and Cox regression models were used to assess the predictors of cancer-specific survival. RTPI was class...Continue Reading

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Citations

Apr 27, 2019·World Journal of Urology·Rocco PapaliaGiovanni Muto
Jan 22, 2020·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Guiya JiangMing Chen
Mar 9, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Yuji NakamotoKaori Togashi
Jan 22, 2021·Journal of Cancer Research and Clinical Oncology·Takashi KuroeGenichiro Ishii
Aug 24, 2019·European Urology Oncology·Hajime TanakaSteven C Campbell

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