Classification of human liver transplant recipients by their preoperative CD8+ T cell subpopulation and its relation to outcome

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Koichi TanakaNagahiro Minato

Abstract

The primed status of T cells is markedly different among liver transplant recipients, due to a lifetime of antigen exposure and reduced thymopoiesis by aging, and diseases. This study aims to characterize the preoperative immunological status of CD8+ T cell subpopulations and relate it to the outcome for liver transplant recipients. We classified 112 liver transplant recipients into 5 groups, based on hierarchical clustering of the CD8+CD45 isoform proportion of T cells. In Groups I and II (pediatric), the naive T cell proportion was more than 50%. In adult recipients, Group III was characterized by a naive T cell proportion of 50%, Group IV had the greatest effector/memory T cells (EM), and Group V had the greatest proportion of effector T cells. In Groups IV and V, the effector T cell proportion was considerably higher, and was accompanied by marked downregulation of the CD27+CD28+ subsets and upregulation of interferon gamma (IFN)-gamma, tumor necrosis factor-alpha, and perforin expression. Group V recipients tended to be complicated postoperatively, with a significantly reduced survival rate (1 yr, 66.8%) and markedly reduced Eastern Cooperative Oncology Group performance status.

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Citations

Apr 9, 2008·Journal of Hepato-biliary-pancreatic Surgery·Hiroto EgawaKazue Ozawa
Dec 17, 2008·Digestive Diseases and Sciences·Hiroto EgawaShinji Uemoto
Oct 1, 2009·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Mario Fernández-RuizJose María Aguado
Oct 12, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hiroto EgawaMotohide Shimazu
Jan 30, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Koichi TanakaKayo Inaba
Sep 1, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Hiroto EgawaKoichi Tanaka
Jul 20, 2010·European Journal of Clinical Investigation·Minoru TanabeMasaki Kitajima

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