PMID: 6966011Jan 15, 1980Paper

Classification of normal and malignant lymphatic cells using acid phosphatase and acid esterase

Klinische Wochenschrift
D HuhnH Rodt

Abstract

The usefulness of cytochemical tests (APh and ANAE) to replace or to supplement membrane markers in subclassification of normal and malignant lymphatic cells was investigated. normal lymphocytes subfractionated by rosetting and centrifugation, and in M. Hodgkin and CLL; lymphoblastoid cell lines; malignant lymphatic cells in different types of lymphatic leukemia. In normal human blood, T-lymphocytes are marked by a distinct "dot-like" ANAE-reactivity which is somewhat less pronounced in the small (11%) subgroup of Fc-IgG-receptor positive T-lymphocytes; B-lymphocytes are negative or finely granular positive. Lymphoblastoid cell lines of B- and of T-type are ANAE- and APh-positive. In some lymphatic malignancies, a characteristic pattern of activity of APh or of ANAE may support the diagnosis. The value of ANAE-cytochemistry is highly estimated for the quantitative determination of the percentage of normal T-lymphocytes lymphatic leukemias, immunological disorders, and during immunosuppressive therapy.

References

Dec 2, 1976·The New England Journal of Medicine·Z FuksH S Kaplan
Jan 1, 1977·Haematology and Blood Transfusion·C RosenfeldG de The
Jun 1, 1977·British Journal of Haematology·J KulenkampffM F Greaves
Jul 15, 1978·Klinische Wochenschrift·D HuhnH Theml
Jan 1, 1978·Acta Haematologica·G A PangalisE Beutler
Aug 1, 1975·European Journal of Immunology·L MorettaM C Mingari
Jul 1, 1974·Journal of Immunological Methods·M E Kaplan, C Clark

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Citations

Jan 2, 1980·Klinische Wochenschrift·D HuhnW Wilmanns
Jan 1, 1985·British Journal of Haematology·J J HoffmannN Swaak-Lammers
Jan 1, 1989·Critical Reviews in Oncology/hematology·B FaliniM F Martelli
Jan 1, 1985·Critical Reviews in Oncology/hematology·E Thiel
Apr 15, 1983·Cancer·D HuhnP Rieber
Nov 1, 1982·European Journal of Immunology·D HuhnG Gastl
Apr 1, 1981·Scandinavian Journal of Haematology·D HuhnP Andreewa
May 1, 1982·Blut·K GrünewaldH Huber

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