Classification of Patients With GH Disorders May Vary According to the IGF-I Assay

The Journal of Clinical Endocrinology and Metabolism
Maria MavromatiPhilippe Chanson

Abstract

Insulinlike growth factor I (IGF-I) measurement is essential for the diagnosis and management of growth hormone (GH) disorders. However, patient classification may vary substantially according to the assay technique. We compared individual patient data and classifications obtained with six different IGF-I assay kits in a group of patients with various GH disorders. In this cross-sectional study, we measured IGF-I with six immunoassays in 102 patients with active or treated acromegaly or GH deficiency. IGF-I normative data previously established for the same six assay kits were used to classify the patients (high, low, or normal IGF-I levels), using both raw data and standard deviation scores (SDSs). Pairwise concordance between assays was assessed with Bland-Altman plots and with the percentage of observed agreement and the weighted κ coefficient for categorized IGF-I SDS. We observed marked variability both across each individual's IGF-I raw data and across IGF-I SDS values obtained with each of the six immunoassays. Pairwise concordance between assay values, as assessed with the weighted κ coefficient, ranged from 0.50 (moderate) to 0.81 (excellent). Even when using normative data obtained in the same large population of heal...Continue Reading

References

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Citations

Jan 7, 2018·Pituitary·Fabienne LangloisMaria Fleseriu
Apr 1, 2018·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Tianyu LuWei Jin
Jan 16, 2020·Archives of Endocrinology and Metabolism·Katharina Schilbach, Martin Bidlingmaier
Jul 28, 2018·Nature Reviews. Endocrinology·Shlomo MelmedAndrea Giustina
Dec 27, 2017·Endocrinology, Diabetes & Metabolism·Robert D'ArcyKaren Mullan
Jun 27, 2019·The New England Journal of Medicine·Shlomo Melmed
Jul 1, 2020·Journal of Endocrinological Investigation·C BonaS Grottoli
Feb 20, 2021·Journal of the Endocrine Society·Maria Laura MonzaniVincenzo Rochira
Oct 14, 2019·Annales d'endocrinologie·Héléna MosbahPhilippe Chanson
Mar 20, 2021·The Journal of Clinical Endocrinology and Metabolism·In-Ho JungEui Hyun Kim
Aug 22, 2021·Nature Reviews. Endocrinology·Camille HageRoberto Salvatori
Jan 27, 2020·Annales d'endocrinologie·Thomas GraillonHenry Dufour

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