Classification of patterns of delirium severity scores over time in an elderly population

International Psychogeriatrics
Marie-Pierre SylvestreMichal Abrahamowicz

Abstract

To describe and classify individual trajectories of 15-day changes in delirium severity. A longitudinal hospital-based study was carried out with 230 medical inpatients aged 65 and over admitted to St Mary's Hospital in Montreal, Canada, between 1996 and 1999, diagnosed with delirium at enrollment, and who had at least four measurements of delirium severity during the next 15 days. Delirium severity was assessed using the Delirium Index (DI). To classify patients' individual trajectories, we applied a new method that relies on principal factor analysis and cluster analysis. We used multiple linear regression to investigate if clusters were associated with DI scores measured at an 8-week follow-up. Multivariable Cox's proportional hazards regression was used to assess whether the clusters were associated with survival over the next 12 months. Individual patterns were classified into five clusters: Steady (n = 89, 38.9%), Fluctuating (n = 36, 15.7%), Worsening (n = 15, 6.6%), Fast Improve-ment (n = 26, 11.3%), and Slow Improvement (n = 63, 27.5%). The Fast Improvement cluster had much lower prevalence of dementia (38.5% vs. 55.6% to 77.8% in other clusters, p = 0.003). Subjects whose 2-week patterns were classified as Fast or Slo...Continue Reading

Citations

Apr 17, 2009·International Psychogeriatrics·Martin G Cole, Jane McCusker
Nov 15, 2011·The British Journal of Psychiatry : the Journal of Mental Science·David MeagherMaeve Leonard
Feb 17, 2009·International Review of Psychiatry·Alasdair M J MacLullichDavid J Meagher
Feb 12, 2013·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Martin G ColeEric Belzile
Aug 19, 2008·Journal of Psychosomatic Research·David J MeagherJouko V Laurila
Aug 11, 2015·International Psychogeriatrics·Jane McCuskerChun Bai
Apr 21, 2012·International Journal of Geriatric Psychiatry·Martin G ColeEric Belzile
Nov 5, 2013·Palliative & Supportive Care·Maeve LeonardDavid Meagher
Jul 21, 2016·Geriatrics & Gerontology International·Carlos Jorge-RipperFrancisco Santolaria
Sep 1, 2016·International Psychogeriatrics·Antonio CiampiEric Belzile
Dec 22, 2016·International Psychogeriatrics·Guk-Hee Suh, Lina Gega
May 4, 2018·International Psychogeriatrics·Antonio CiampiEric Belzile
Mar 13, 2010·Current Opinion in Psychiatry·Martin G Cole
Dec 12, 2018·The Gerontologist·Sean Shenghsiu Huang, John R Bowblis
Nov 26, 2019·JAMA Pediatrics·Mai-Han TrinhEdwina H Yeung
Feb 23, 2019·Cell Communication and Signaling : CCS·Jaime Santo-DomingoAndreas Wiederkehr
May 10, 2020·Annals of the American Thoracic Society·Heidi LindrothMalaz A Boustani
Jun 12, 2021·Frontiers in Psychology·Roberta SimeoliDavide Marocco
Sep 27, 2020·Critical Care : the Official Journal of the Critical Care Forum·Zudin A PuthuchearyKonrad F R Schmidt

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