PMID: 3760923Aug 1, 1986Paper

Classification of primate spinothalamic and somatosensory thalamic neurons based on cluster analysis

Journal of Neurophysiology
J M ChungW D Willis

Abstract

Data analyzed in this study were derived from the responses of 128 spinothalamic tract (STT) cells and 110 thalamic neurons recorded in 75 anesthetized monkeys. A k-means cluster analysis, a nonhierarchical clustering technique, was performed using the relative magnitudes of responses to a graded series of innocuous and noxious mechanical stimuli applied to the receptive field. For comparison, a parallel analysis was performed based on definitions of low-threshold (LT), wide dynamic range (WDR), and high-threshold (HT) cells used by our laboratory. For 128 STT cells, a classification scheme with three clusters was found statistically to be the best. This yielded groups of 22, 57, and 49 cells in clusters 1, 2, and 3, respectively. Cluster 1 cells were activated best by low-intensity mechanical stimuli, whereas cluster 3 cells were activated primarily by nociceptive stimuli. Cluster 2 cells had intermediate characteristics. When the classification scheme based on the cluster analysis was compared with the classification of the same neurons as LT, WDR, and HT cells, cluster 1 cells were divided into LT and WDR cells, whereas cluster 2 and 3 cells included WDR and HT cells. For 110 thalamic neurons, a classification scheme with fi...Continue Reading

Citations

Mar 14, 2003·Journal of Neurophysiology·Yuan Bo PengDaniel R Kenshalo
Dec 27, 2013·Brain : a Journal of Neurology·Guillaume LavertuYves De Koninck
May 10, 2017·Neuroscience Bulletin·Bo DuanQiufu Ma
Jan 1, 1991·Somatosensory & Motor Research·J Y Wei, R P Tuckett
Jan 1, 1988·Annals of the New York Academy of Sciences·W D Willis
Jan 1, 1997·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·W D Willis, K N Westlund
Oct 12, 2010·Journal of Neurophysiology·M Danilo BoadaDouglas G Ririe
Sep 28, 2017·Neural Plasticity·Young S GwakJoong Woo Leem
Jan 20, 2020·Cellular and Molecular Neurobiology·Jonghoon KangYoung S Gwak
Aug 13, 2011·Journal of Neurophysiology·Christopher E HagainsYuan B Peng
Feb 12, 1999·Brain Research. Brain Research Reviews·G W Lu, W D Willis

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