Classification of terahertz-pulsed imaging data from excised breast tissue

Journal of Biomedical Optics
Anthony J FitzgeraldVincent P Wallace

Abstract

We investigate the efficacy of using data reduction techniques to aid classification of terahertz (THz) pulse data obtained from tumor and normal breast tissue. Fifty-one samples were studied from patients undergoing breast surgery at Addenbrooke's Hospital in Cambridge and Guy's Hospital in London. Three methods of data reduction were used: ten heuristic parameters, principal components of the pulses, and principal components of the ten parameter space. Classification was performed using the support vector machine approach with a radial basis function. The best classification accuracy, when using all ten components, came from using the principal components on the pulses and principal components on the parameter, with an accuracy of 92%. When less than ten components were used, the principal components on the parameter space outperformed the other methods. As a visual demonstration of the classification technique, we apply the data reduction/classification to several example images and demonstrate that, aside from some interpatient variability and edge effects, the algorithm gives good classification on terahertz data from breast tissue. The results indicate that under controlled conditions data reduction and SVM classification...Continue Reading

References

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Citations

Feb 20, 2016·Scientific Reports·Yuying JiangShanhong Xia
Mar 10, 2016·Artificial Intelligence in Medicine·Xiao-Xia YinDerek Abbott
Aug 3, 2013·Scientific Reports·Kyu-Tae KimGun-Sik Park
Oct 28, 2014·IEEE Transactions on Bio-medical Engineering·Bao C Q TruongH T Nguyen
Jul 24, 2014·IEEE Journal of Biomedical and Health Informatics·Caroline B ReidVincent P Wallace
Jul 24, 2014·IEEE Journal of Biomedical and Health Informatics·Benjamin St PeterAndrew Karellas
Mar 9, 2017·Biomedical Optics Express·Jae Yeon ParkJoo-Hiuk Son
Feb 16, 2018·Journal of Biomedical Optics·Tyler BowmanMagda El-Shenawee
Nov 11, 2018·Biotechnology Progress·Guoshuai GengHuabin Wang
May 17, 2019·Journal of Medical Imaging·Tyler BowmanMagda El-Shenawee
Sep 26, 2017·Physics in Medicine and Biology·Yuezhi HeEmma PickWell-MacPherson
Mar 16, 2018·Biomedical Optics Express·Bao C Q TruongVincent P Wallace
Jul 10, 2018·Biomedical Optics Express·Quentin CassarPatrick Mounaix
Jul 1, 2017·Biomedical Optics Express·Maarten R GrootendorstArnie Purushotham
Apr 16, 2019·Journal of Infrared, Millimeter and Terahertz Waves·Tanny ChavezMagda El-Shenawee
Mar 21, 2020·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Dandan LiHuabin Wang
Sep 24, 2021·Journal of Biophotonics·Limin WuJianquan Yao

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