Classification of voluntary cough airflow patterns for prediction of abnormal spirometry

IEEE Journal of Biomedical and Health Informatics
Jeffrey ReynoldsDavid Frazer

Abstract

Measurement of partial expiratory flow-volume curves has become an important technique in diagnosing lung disease, particularly in children and in the elderly. The objective of this study was to investigate the feasibility of predicting abnormal spirometry using the partial flow-volume curve generated during a voluntary cough. Here, abnormal spirometry is defined as less than the lower limit of normal (LLN) predicted by standard reference equations [1]. Cough airflow signals of 107 subjects (56 male, 51 female) were previously collected [2] from patients performing spirometry in a pulmonary function clinic. A variety of features were extracted from the airflow signal. A support vector machine (SVM) classifier was developed to predict abnormal spirometry. Airflow signal features and SVM parameters were selected using a genetic algorithm. The ability of the classifier to distinguish between normal and abnormal spirometry based on cough flow was evaluated by comparing the classifiers decisions with the LLN for the given subject's spirometry, including forced expiratory volume in one second (FEV1), forced vital capacity (FV C), and their ratio (FEV1=FV C%). Findings indicated that it was possible to classify patients whose spiromet...Continue Reading

References

Sep 1, 1991·Computer Methods and Programs in Biomedicine·C W ThorpeK P Dawson
Jan 1, 1989·Pediatric Pulmonology·C S BeardsmoreH Simpson
Jan 1, 1988·Pediatric Pulmonology·W J MorganL M Taussig
Sep 1, 1995·American Journal of Respiratory and Critical Care Medicine
Jan 5, 1999·American Journal of Respiratory and Critical Care Medicine·J L HankinsonK B Fedan
Oct 31, 2009·Annals of Biomedical Engineering·W T GoldsmithD G Frazer
Mar 12, 2010·Methods in Molecular Biology·Asa Ben-Hur, Jason Weston

❮ Previous
Next ❯

Citations

Jan 17, 2017·IEEE Journal of Biomedical and Health Informatics·Daniel KellyBrian Caulfield
Sep 8, 2017·IEEE Journal of Biomedical and Health Informatics·Hanguang XiaoAlberto P Avolio
Aug 10, 2018·Physiological Measurement·Roneel V SharanPaul Porter

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of the American Geriatrics Society
Simone ScarlataRaffaele Antonelli Incalzi
American Journal of Respiratory and Critical Care Medicine
Michal KulichBonnie Ramsey
Heart & Lung : the Journal of Critical Care
Armine G MinasianYvonne F Heijdra
© 2021 Meta ULC. All rights reserved