Classifying atopic dermatitis: protocol for a systematic review of subtypes (phenotypes) and associated characteristics

BMJ Open
Amy R MulickSinéad M Langan

Abstract

Atopic dermatitis is a complex disease with differing clinical presentations. Many attempts have been made to identify uniform subtypes, or phenotypes, of atopic dermatitis in order to identify different aetiologies, improve diagnosis, estimate more accurate clinical prognoses, inform treatment andmanagement or predict treatment efficacy andeffectiveness. However, no consensus yet exists on exactly what defines these phenotypes or how many there are and whether they are genuine or statistical artefacts. This review aims to identify previously reported phenotypes of atopic dermatitis, the features used to define them and any characteristics or clinical outcomes significantly associated with them. We will search Ovid Embase, Ovid MEDLINE and Web of Science from inception to the latest available date at the time of the search for studies attempting to classify atopic dermatitis in humans using any cross-sectional or longitudinal epidemiological or interventional design. Primary outcomes are atopic dermatitis phenotypes, features used to define them and characteristics associated with them in subsequent analyses. A secondary outcome is the methodological approach used to derive them. Two reviewers will independently screen titles a...Continue Reading

References

Jul 9, 2004·The Journal of Allergy and Clinical Immunology·Carsten FlohrHywel Williams
Jul 4, 2006·The Journal of Allergy and Clinical Immunology·Hywel Williams, Carsten Flohr
Mar 7, 2007·Acta Dermato-venereologica·Jochen SchmittMichael Meurer
Jun 23, 2009·The Journal of Allergy and Clinical Immunology·Lisa A BeckDonald Y M Leung
Jan 21, 2011·Journal of Clinical Epidemiology·Gordon H GuyattHolger J Schünemann
Oct 6, 2014·The Journal of Allergy and Clinical Immunology·Donald Y M Leung, Emma Guttman-Yassky
Oct 3, 2015·The Journal of Allergy and Clinical Immunology·Shinji NodaEmma Guttman-Yassky
Nov 14, 2017·The Journal of Allergy and Clinical Immunology·Lavinia PaternosterSara J Brown
Feb 23, 2018·JCI Insight·Evgeny BerdyshevDonald Ym Leung
May 8, 2018·The Journal of Allergy and Clinical Immunology·Patrick M BrunnerEmma Guttman-Yassky

❮ Previous
Next ❯

Citations

Feb 27, 2020·Clinical and Translational Allergy·Chen HuLiesbeth Duijts
Nov 23, 2020·Archives of Dermatological Research·Marissa T AyasseJonathan I Silverberg
Apr 16, 2021·Therapeutic Advances in Chronic Disease·Giampiero GirolomoniAna B Rossi

❮ Previous
Next ❯

Software Mentioned

Ovid Embase
Covidence
Ovid MEDLINE

Related Concepts

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.