Abstract
Atopic dermatitis is a complex disease with differing clinical presentations. Many attempts have been made to identify uniform subtypes, or phenotypes, of atopic dermatitis in order to identify different aetiologies, improve diagnosis, estimate more accurate clinical prognoses, inform treatment andmanagement or predict treatment efficacy andeffectiveness. However, no consensus yet exists on exactly what defines these phenotypes or how many there are and whether they are genuine or statistical artefacts. This review aims to identify previously reported phenotypes of atopic dermatitis, the features used to define them and any characteristics or clinical outcomes significantly associated with them. We will search Ovid Embase, Ovid MEDLINE and Web of Science from inception to the latest available date at the time of the search for studies attempting to classify atopic dermatitis in humans using any cross-sectional or longitudinal epidemiological or interventional design. Primary outcomes are atopic dermatitis phenotypes, features used to define them and characteristics associated with them in subsequent analyses. A secondary outcome is the methodological approach used to derive them. Two reviewers will independently screen titles a...Continue Reading
References
May 8, 2004·The Journal of Allergy and Clinical Immunology·S G O JohanssonHywel C Williams
Jul 9, 2004·The Journal of Allergy and Clinical Immunology·Carsten FlohrHywel Williams
Jul 1, 2006·The Journal of Investigative Dermatology·Aileen SandilandsAlan D Irvine
Jul 4, 2006·The Journal of Allergy and Clinical Immunology·Hywel Williams, Carsten Flohr
Mar 7, 2007·Acta Dermato-venereologica·Jochen SchmittMichael Meurer
Jun 23, 2009·The Journal of Allergy and Clinical Immunology·Lisa A BeckDonald Y M Leung
Aug 18, 2009·The British Journal of Dermatology·S J BrownN J Reynolds
Dec 9, 2010·The British Journal of Dermatology·C FlohrG Lack
Jan 21, 2011·Journal of Clinical Epidemiology·Gordon H GuyattHolger J Schünemann
Nov 11, 2011·The Journal of Investigative Dermatology·Sara J BrownAlan D Irvine
Mar 5, 2013·Allergy·D GarmhausenN Novak
Oct 6, 2014·The Journal of Allergy and Clinical Immunology·Donald Y M Leung, Emma Guttman-Yassky
Oct 3, 2015·The Journal of Allergy and Clinical Immunology·Shinji NodaEmma Guttman-Yassky
May 23, 2017·JAMA Pediatrics·Caroline RoduitGert Doekes
Nov 14, 2017·The Journal of Allergy and Clinical Immunology·Lavinia PaternosterSara J Brown
Feb 23, 2018·JCI Insight·Evgeny BerdyshevDonald Ym Leung
May 8, 2018·The Journal of Allergy and Clinical Immunology·Patrick M BrunnerEmma Guttman-Yassky
Citations
Feb 27, 2020·Clinical and Translational Allergy·Chen HuLiesbeth Duijts
Nov 23, 2020·Archives of Dermatological Research·Marissa T AyasseJonathan I Silverberg
Dec 6, 2020·Science Advances·Surabhi R MadhvapathyJohn A Rogers
Apr 16, 2021·Therapeutic Advances in Chronic Disease·Giampiero GirolomoniAna B Rossi