Classifying MCI Subtypes in Community-Dwelling Elderly Using Cross-Sectional and Longitudinal MRI-Based Biomarkers

Frontiers in Aging Neuroscience
Hao GuanWei Wen

Abstract

Amnestic MCI (aMCI) and non-amnestic MCI (naMCI) are considered to differ in etiology and outcome. Accurately classifying MCI into meaningful subtypes would enable early intervention with targeted treatment. In this study, we employed structural magnetic resonance imaging (MRI) for MCI subtype classification. This was carried out in a sample of 184 community-dwelling individuals (aged 73-85 years). Cortical surface based measurements were computed from longitudinal and cross-sectional scans. By introducing a feature selection algorithm, we identified a set of discriminative features, and further investigated the temporal patterns of these features. A voting classifier was trained and evaluated via 10 iterations of cross-validation. The best classification accuracies achieved were: 77% (naMCI vs. aMCI), 81% (aMCI vs. cognitively normal (CN)) and 70% (naMCI vs. CN). The best results for differentiating aMCI from naMCI were achieved with baseline features. Hippocampus, amygdala and frontal pole were found to be most discriminative for classifying MCI subtypes. Additionally, we observed the dynamics of classification of several MRI biomarkers. Learning the dynamics of atrophy may aid in the development of better biomarkers, as it m...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Nov 1, 1984·The American Journal of Psychiatry·W G RosenK L Davis
Jan 1, 1993·European Neurology·H BraakJ Bohl
Aug 26, 1998·Dementia and Geriatric Cognitive Disorders·I HindmarchH Erzigkeit
Jan 21, 2004·Archives of Neurology·Michael GrundmanUNKNOWN Alzheimer's Disease Cooperative Study
Aug 25, 2004·Journal of Internal Medicine·R C Petersen
Aug 9, 2006·Archives of General Psychiatry·Matthias H TabertD P Devanand
Aug 19, 2007·Archives of Neurology·Jennifer L WhitwellClifford R Jack
Dec 7, 2007·Medical Image Computing and Computer-assisted Intervention : MICCAI·Z Y SunJ F Mangin
Dec 17, 2008·NeuroImage·Francisco PereiraMatthew Botvinick
Mar 3, 2009·Magnetic Resonance Imaging·John Ashburner
Apr 28, 2009·Nature Neuroscience·Nikolaus KriegeskorteChris I Baker
May 11, 2010·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·John Q TrojanowskiUNKNOWN Alzheimer's Disease Neuroimaging Initiative
May 21, 2010·Neurology·Ronald C Petersen
Jun 15, 2010·NeuroImage·Rémi CuingnetUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jul 3, 2010·Neurobiology of Aging·Christos DavatzikosJohn Q Trojanowski
Jul 14, 2010·Neurobiology of Aging·Shannon L RisacherUNKNOWN Alzheimer's Disease Neuroimaging Initiative (ADNI)
Jan 18, 2011·NeuroImage·Daoqiang ZhangUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jan 29, 2011·Neurobiology of Aging·Yang LiUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Mar 1, 2011·NeuroImage·Brian PatenaudeMark Jenkinson
Mar 8, 2011·NeuroImage·Martin Reuter, Bruce Fischl
Apr 8, 2011·Radiology·Linda K McEvoyUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Aug 10, 2011·Archives of Neurology·Mert R SabuncuUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jan 28, 2012·Journal of the Neurological Sciences·Haobo ZhangJulian N Trollor
Mar 13, 2012·Neurobiology of Aging·Junming ShaoChristian Sorg
Mar 21, 2012·NeuroImage·Martin ReuterBruce Fischl
Mar 30, 2012·PloS One·Daoqiang ZhangUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Oct 6, 2012·NeuroImage·Simon F EskildsenUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Nov 1, 2012·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Henry BrodatyPerminder S Sachdev
Apr 16, 2013·NeuroImage·Jiayu ZhouUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Aug 21, 2013·Neurobiology of Aging·Paula T TrzepaczUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Sep 10, 2013·Neuroinformatics·Benson MwangiJair C Soares
Nov 2, 2013·NeuroImage·Rashmi DubeyUNKNOWN Alzheimer's Disease Neuroimaging Initiative

❮ Previous
Next ❯

Citations

Jun 9, 2020·Journal of Alzheimer's Disease : JAD·Dale S ShermanDavid M Ross
Dec 1, 2018·Japanese Journal of Radiology·Koji Sakai, Kei Yamada
Jan 30, 2020·Computer Methods and Programs in Biomedicine·Gerard Martí-JuanGemma Piella
May 1, 2021·Pharmaceuticals·Carlo TominoPaolo Maria Rossini
Jul 27, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Chao DuZhanjun Zhang
Aug 31, 2021·Frontiers in Aging Neuroscience·Stephanie FröhlichClaudia Voelcker-Rehage
Jan 28, 2022·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Ranjan Duara, Warren Barker

❮ Previous
Next ❯

Software Mentioned

SPM5
FIRST ( FMRIB Image Registration and Segmentation Tool
BrainVisa
Learn
Numpy
FreeSurfer
Scipy
FSL
Scikit

Related Concepts

Related Feeds

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Related Papers

The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry
Ranjan DuaraHuntington Potter
Neurobiology of Aging
Simon F EskildsenAlzheimer's Disease Neuroimaging Initiative
© 2022 Meta ULC. All rights reserved