Classifying murine glomerulonephritis using optical coherence tomography and optical coherence elastography

Journal of Biophotonics
Chih-hao LiuKirill V Larin

Abstract

Acute glomerulonephritis caused by antiglomerular basement membrane marked by high mortality. The primary reason for this is delayed diagnosis via blood examination, urine analysis, tissue biopsy, or ultrasound and X-ray computed tomography imaging. Blood, urine, and tissue-based diagnoses can be time consuming, while ultrasound and CT imaging have relatively low spatial resolution, with reduced sensitivity. Optical coherence tomography is a noninvasive and high-resolution imaging technique that provides superior spatial resolution (micrometer scale) as compared to ultrasound and CT. Changes in tissue properties can be detected based on the optical metrics analyzed from the OCT signals, such as optical attenuation and speckle variance. Furthermore, OCT does not rely on ionizing radiation as with CT imaging. In addition to structural changes, the elasticity of the kidney can significantly change due to nephritis. In this work, OCT has been utilized to quantify the difference in tissue properties between healthy and nephritic murine kidneys. Although OCT imaging could identify the diseased tissue, its classification accuracy is clinically inadequate. By combining optical metrics with elasticity, the classification accuracy improv...Continue Reading

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Citations

Mar 9, 2017·Biomedical Optics Express·Kirill V Larin, David D Sampson
Mar 9, 2017·Biomedical Optics Express·Chih-Hao LiuKirill V Larin
Jul 26, 2019·Journal of Biophotonics·Chih-Hao LiuKirill V Larin
Aug 3, 2016·Journal of Biophotonics·Alex VitkinElena Zagaynova
Oct 28, 2019·Biomedical Optics Express·Arata MiyazawaYoshiaki Yasuno

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