Abstract
Glyphosate (N-(phosphonomethyl) glycine, C(3)H(8)NO(5)P), a herbicide, used to control unwanted annual and perennial plants all over the world. Nevertheless, occupational and environmental exposure to pesticides can pose a threat to nontarget species including human beings. Therefore, in the present study, genotoxic effects of the herbicide glyphosate were analyzed by measuring chromosomal aberrations (CAs) and micronuclei (MN) in bone marrow cells of Swiss albino mice. A single dose of glyphosate was given intraperitoneally (i.p) to the animals at a concentration of 25 and 50 mg/kg b.wt. Animals of positive control group were injected i.p. benzo(a)pyrene (100 mg/kg b.wt., once only), whereas, animals of control (vehicle) group were injected i.p. dimethyl sulfoxide (0.2 mL). Animals from all the groups were sacrificed at sampling times of 24, 48, and 72 hours and their bone marrow was analyzed for cytogenetic and chromosomal damage. Glyphosate treatment significantly increases CAs and MN induction at both treatments and time compared with the vehicle control (P < .05). The cytotoxic effects of glyphosate were also evident, as observed by significant decrease in mitotic index (MI). The present results indicate that glyphosate is...Continue Reading
References
Feb 1, 1975·Mutation Research·W Schmid
Jan 1, 1991·Environmental and Molecular Mutagenesis·J A HeddleJ T MacGregor
Apr 1, 1988·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·A P Li, T J Long
Oct 1, 1987·Mutation Research·R J PrestonM Shelby
Jan 1, 1982·Environmental Mutagenesis·J C Liang, M E Gaulden
Mar 1, 1983·Mutation Research·M MoriyaY Shirasu
May 1, 1982·Mutation Research·K H LarsenG A Sega
Jun 1, 1993·Mutation Research·J RankK Jensen
Jan 1, 1995·Environmental and Molecular Mutagenesis·P G KaleY R Sohni
Feb 1, 1995·Cancer Genetics and Cytogenetics·S BonassiP Padovani
Nov 1, 1995·Environmental Health Perspectives·A Blair, S H Zahm
Jan 1, 1997·Environmental and Molecular Mutagenesis·C ClementsM Petras
Feb 17, 1998·Environmental and Molecular Mutagenesis·M PelusoS Parodi
Aug 26, 1998·Environmental and Molecular Mutagenesis·M B LioiM V Ursini
Mar 10, 2000·Mutation Research·B KayaR Marcos
Feb 7, 2001·American Journal of Epidemiology·R MeinertJ Michaelis
Jun 15, 2000·Regulatory Toxicology and Pharmacology : RTP·G M WilliamsI C Munro
Aug 31, 2000·Environmental Health Perspectives·L P WalshD M Stocco
Dec 5, 2000·Scandinavian Journal of Work, Environment & Health·B F LanderH Norppa
Dec 13, 2000·Mutation Research·M Fenech
Jan 9, 2001·American Journal of Industrial Medicine·B T JiR N Hoover
Mar 10, 2001·Environmental Research·J DaruichM S Gimenez
Apr 12, 2002·Cancer Genetics and Cytogenetics·Lucy R WebsterHelen T Moriarty
May 16, 2002·Journal of Agricultural and Food Chemistry·Shouxun ZhaoGeorge Eadon
Feb 21, 2003·American Journal of Industrial Medicine·Tim Clary, Beate Ritz
Jun 26, 2003·Journal of Agricultural and Food Chemistry·Gail A BresnahanMonisha Chakraborty
Mar 10, 2005·Mutagenesis·Mustafa CelikResat Kasap
Dec 24, 2005·International Journal of Hygiene and Environmental Health·Katarína Siviková, Ján Dianovskỳ
Sep 26, 2006·Mutagenesis·Boyan D DimitrovMaria V Bineva
Jul 19, 2008·Journal of Applied Toxicology : JAT·M F SimonielloM A Carballo
Nov 22, 2008·Mutation Research·G L PolettaM D Mudry
Citations
Mar 5, 2013·Aquatic Toxicology·Sushama Singh YadavAnirudha Giri
Aug 24, 2011·Journal of Medicinal Food·Kültiğin CavuşoğluEmine Yalçın
Jul 24, 2014·Pesticide Biochemistry and Physiology·Magdalena ChłopeckaWojciech Karlik
Dec 22, 2015·Chemosphere·Nédia de Castilhos GhisiAlberto José Prioli
Apr 24, 2012·Environmental Toxicology and Pharmacology·Celine HeuLaurence Nicod
Mar 1, 2012·Journal of Structural Biology·Celine HeuLaurence Nicod
Jan 5, 2010·Journal of Proteomics·Jasmine GeorgeYogeshwer Shukla
Aug 19, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R MesnageG E Séralini
May 31, 2012·Environmental Toxicology·Ptumporn MuangphraRavi Gooneratne
Aug 16, 2011·Acta Biologica Hungarica·Elena TrutaZenovia Olteanu
May 31, 2014·Chemosphere·A RoustanC Di Giorgio
Mar 13, 2014·Journal of Toxicology and Environmental Health. Part a·Neide ArmiliatoEvelise M Nazari
May 28, 2016·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Mohammad Iqbal LoneWaseem Ahmad
Sep 30, 2016·Critical Reviews in Toxicology·David BrusickGary Williams
Apr 2, 2014·Genetics and Molecular Biology·Carlos Alvarez-MoyaAlfredo Feria Velasco
May 17, 2017·Environmental Science and Pollution Research International·Tatiana Vieira Souza ChavesMaria Elisabete Amaral de Moraes
Oct 31, 2018·Bulletin of Environmental Contamination and Toxicology·Cátia Cappelli WachtelNédia de Castilhos Ghisi
Apr 30, 2013·Environmental and Molecular Mutagenesis·Fabio Leonardo Meza-JoyaJorge Luis Fuentes-Lorenzo
Dec 13, 2019·Pest Management Science·Xiaoyu LiangYu Zhang
Aug 20, 2016·Environmental Science and Pollution Research International·Shahla Hosseini Bai, Steven M Ogbourne
May 11, 2018·Drug and Chemical Toxicology·Eyyüp Rencüzoğulları, Muhsin Aydın
Oct 28, 2016·Drug and Chemical Toxicology·Lucila Álvarez-BarreraMario A Altamirano-Lozano
Nov 14, 2017·Journal of Toxicology·Karen Suárez-LariosRegina Montero-Montoya
Apr 24, 2019·Scientific Reports·Deepika KubsadMichael K Skinner
Oct 7, 2020·Toxics·Nazia NazamWaseem Ahmad
Feb 9, 2021·Veterinary Medicine and Science·Valence Bwana MutweduRodrigue Basengere Balthazar Ayagirwe
Feb 23, 2021·Toxicology Research·Lécio Leone AlmeidaJoaquim Evêncio Neto
Jun 11, 2021·Frontiers in Public Health·Károly NagyBalázs Ádám
Jun 27, 2021·Environmental Science and Pollution Research International·Fernanda de Maria SerraGisele Alborghetti Nai