Clastogenic factors in plasma of HIV-1 infected patients

Free Radical Biology & Medicine
J FuchsR Milbradt

Abstract

The objective of this study was to investigate the clastogenic activity of plasma ultrafiltrates from HIV-1 infected patients. Clastogenic factors are chromosome-damaging agents with low molecular weight (< 10,000 daltons) which cause chromosome aberrations, sister chromatid exchanges, DNA strand breakage, and gene mutation. They have first been described in the plasma of irradiated persons, but they are also found in hereditary breakage syndromes and chronic inflammatory diseases with autoimmune reactions. Their formation and their clastogenic effects are modulated by superoxide anion radicals. We analyzed a total of 22 HIV-1 positive patients in comparison to 20 reference plasma samples from healthy HIV negative blood donors of similar age. The plasma ultrafiltrates (filter cutoff 10,000 daltons) from patients induced a statistically significant increase in chromosomal breakage in the cytogenetic test system (20.5 +/- 6.8 aberrations per 100 cells), while no increase was observed in test cultures exposed to plasma ultrafiltrates from healthy blood donors (6.3 +/- 2.9 aberrations per 100 cells). The breakage values were slightly, but not significantly, lower in the 10 patients with more than 200 T-helper cells/ml (18 +/- 4 abe...Continue Reading

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Citations

Jan 1, 1997·Biological Trace Element Research·E Peterhans
Dec 21, 2000·Free Radical Biology & Medicine·M VianaB Bonet
Mar 7, 2001·Antioxidants & Redox Signaling·M ParolaM U Dianzani
Jun 6, 2014·International Journal of Cell Biology·Mohammad Latif ReshiJiann-Ruey Hong
Dec 3, 2013·Journal of Sports Sciences·Alesandro GarciaFabricio Azevedo Voltarelli
Apr 15, 2014·Journal of Ethnopharmacology·Jagruti J PatelNiyati S Acharya
Sep 8, 2004·Experimental and Molecular Pathology·William E Stehbens
Jan 1, 2017·Archives of Virology·Fernanda Caetano CaminiCintia Lopes de Brito Magalhães
Sep 19, 2019·Archives of Virology·Agieshkumar Balakrishna PillaiSoundravally Rajendiran

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