Clastogenicity of diepoxybutane in bone marrow cells and male germ cells of mice

Mutagenesis
I D AdlerF Pacchierotti

Abstract

The bifunctional metabolite of 1,3-butadiene, 1,2:3,4-diepoxybutane (DEB), was tested in the mouse bone marrow micronucleus assay and in male mouse germ cell tests, namely the analysis of first cleavage divisions and the dominant lethal assay. All experiments were performed with single intraperitoneal treatment of the animals. In the micronucleus test, DEB doses of 4.5, 9.0, 18.0 and 36.0 mg/kg body weight were tested at a sampling interval of 24 h for bone marrow. The dose response for the induction of micronuclei in polychromatic erythrocytes was linear with the lowest effective dose of 9.0 mg/kg body weight. No sensitivity difference was observed between male and female mice. the cytogenetic analysis of first cleavage division chromosomes was performed after treatment of male mice with 17, 26, 34, 43 and 52 mg/kg body weight of DEB and mating the males to hormonally stimulated females on days 7, 14, 21 and 28 after treatment. The two higher doses caused general toxicity evidenced by the poor mating behavior of the males. Only 13 and 20% of the mated females were fertilized on day 7 after treatment of the males with 43 and 52 mg/kg body weight of DEB, respectively. An increased number of unfertilized oocytes was obtained from...Continue Reading

Citations

Jun 12, 1996·Mutation Research·I D AdlerA D Tates
Jun 9, 2001·Chemico-biological Interactions·D Anderson
Jun 9, 2001·Chemico-biological Interactions·K HughesM Walker
Jun 9, 2001·Chemico-biological Interactions·J A Bond, M A Medinsky
Feb 17, 1998·Mutation Research·M H BrinkworthE Nieschlag
Feb 17, 1998·Mutation Research·F PacchierottiR Waters
Feb 18, 2003·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·K HughesR Beauchamp
Jul 22, 2005·Birth Defects Research. Part C, Embryo Today : Reviews·Francesco Marchetti, Andrew J Wyrobek
Dec 13, 2006·Environmental Research·Ursula Eichenlaub-RitterFrancesca Pacchierotti
Sep 28, 2010·Critical Reviews in Toxicology·Richard J AlbertiniMichael L Gargas

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