Clathrin assembly proteins AP180 and CALM in the embryonic rat brain.

The Journal of Comparative Neurology
Catherine M SchwartzPamela J Yao

Abstract

Clathrin-coated vesicles are known to play diverse and pivotal roles in cells. The proper formation of clathrin-coated vesicles is dependent on, and highly regulated by, a large number of clathrin assembly proteins. These assembly proteins likely determine the functional specificity of clathrin-coated vesicles, and together they control a multitude of intracellular trafficking pathways, including those involved in embryonic development. In this study, we focus on two closely related clathrin assembly proteins, AP180 and CALM (clathrin assembly lymphoid myeloid leukemia protein), in the developing embryonic rat brain. We find that AP180 begins to be expressed at embryonic day 14 (E14), but only in postmitotic cells that have acquired a neuronal fate. CALM, on the other hand, is expressed as early as E12, by both neural stem cells and postmitotic neurons. In vitro loss-of-function studies using RNA interference (RNAi) indicate that AP180 and CALM are dispensable for some aspects of embryonic neurogenesis but are required for the growth of postmitotic neurons. These results identify the developmental stage of AP180 and CALM expression and suggest that each protein has distinct functions in neural development.

References

Jan 1, 1988·Cell Motility and the Cytoskeleton·J L Lessard
May 14, 1996·Proceedings of the National Academy of Sciences of the United States of America·M H DreylingS K Bohlander
Dec 16, 1997·Proceedings of the National Academy of Sciences of the United States of America·M P SmidtJ P Burbach
Nov 6, 1998·Science·J A ThomsonJ M Jones
Feb 27, 1999·Protein Science : a Publication of the Protein Society·B K KayS D Emr
Aug 4, 1999·Proceedings of the National Academy of Sciences of the United States of America·L M TraubD H Fremont
Mar 23, 2002·Science·Thijn R BrummelkampReuven Agami
Apr 27, 2002·The Journal of Comparative Neurology·Pamela J YaoDavid J Calkins
Jul 18, 2002·Traffic·Eileen M Lafer
Nov 14, 2002·Neuromolecular Medicine·Jennifer R MorganEileen M Lafer
Sep 2, 2003·Neuron·Victoria GrahamLarysa Pevny
Oct 7, 2003·Annual Review of Neuroscience·Venkatesh N Murthy, Pietro De Camilli
Apr 7, 2004·Trends in Cell Biology·Margaret S Robinson
Aug 5, 2004·The Journal of Biological Chemistry·Sanjay K MishraLinton M Traub
Nov 24, 2004·The Journal of Comparative Neurology·Pamela J YaoKatsutoshi Furukawa
Nov 3, 2005·The European Journal of Neuroscience·Takashi NambaTatsunori Seki
Nov 25, 2005·Stem Cells and Development·Catherine M SchwartzMahendra S Rao
Dec 2, 2005·The Journal of Comparative Neurology·Pamela J YaoRonald S Petralia
Jun 30, 2006·Current Opinion in Cell Biology·Timothy A Ryan
Jun 30, 2006·Current Opinion in Cell Biology·Tom J Brett, Linton M Traub
Jul 17, 2007·Current Opinion in Cell Biology·Ernst J Ungewickell, Lars Hinrichsen
Jul 21, 2007·The Journal of Comparative Neurology·Ronald S Petralia, Pamela J Yao
Aug 24, 2007·Nature·Eva M Schmid, Harvey T McMahon
Nov 21, 2007·Stem Cells·Candace L KerrJohn D Gearhart
Jan 10, 2008·Traffic·Asaff HarelPamela J Yao
Oct 10, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ittai BushlinPamela J Yao
May 19, 2009·Nature Neuroscience·Andrée Gauthier-FisherFreda D Miller

❮ Previous
Next ❯

Citations

Aug 2, 2012·Neuromolecular Medicine·Ronald S PetraliaPamela J Yao
Sep 7, 2012·PloS One·Paula B ScotlandDaniel S Wechsler
Jan 12, 2011·Neuromolecular Medicine·Asaff HarelPamela J Yao
Nov 4, 2015·Journal of Neuroscience Research·Sabine Ulrike VayMaria Adele Rueger
Jul 30, 2011·The Journal of Comparative Neurology·Michael PiperLinda J Richards
May 30, 2012·Biology of the Cell·Tanja MaritzenVolker Haucke
Oct 13, 2010·Biochemical and Biophysical Research Communications·Fangbai WuPamela J Yao
Jun 5, 2019·Molecular Neurodegeneration·Zoë P Van AckerWim Annaert
Apr 26, 2021·The FEBS Journal·Santiago Camblor-Perujo, Natalia L Kononenko

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Ittai BushlinPamela J Yao
Biochemical and Biophysical Research Communications
Fangbai WuPamela J Yao
© 2021 Meta ULC. All rights reserved