Clathrin gene expression is androgen regulated in the prostate

Endocrinology
J L Prescott, Donald J Tindall

Abstract

Androgens are required for the development and function of the prostate. In a normal human prostate, androgens control the synthesis of proteins such as prostate-specific antigen and human glandular kallikrein. The prostate secretes these proteins as well as a number of other compounds to form the prostatic fluid. Using differential display PCR to detect novel androgen-regulated genes, clathrin heavy chain expression was identified as potentially being up-regulated by androgens in the prostate cancer cell line LNCaP. We report here that the clathrin heavy chain and light chain genes are regulated by androgens. Clathrin heavy chain messenger RNA was up-regulated by androgens in a concentration- and time-specific manner in the LNCaP cell line. Translation of clathrin heavy chain messenger RNA was stimulated by androgens. Steady state levels of clathrin light chains a and b were up-regulated in the presence of androgen in LNCaP cells. Clathrin gene expression was examined in normal rat prostates, and similar results were found. Clathrin heavy chain protein levels in the rat prostate are also affected by the androgen status of the animal. We hypothesize that clathrin may be involved in the exocytosis of androgen-regulated secretory...Continue Reading

References

Jan 1, 1986·The Prostate·L R MurthyD J Tindall
Aug 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·L OrciA Perrelet
Jan 1, 1994·Vitamins and Hormones·J LindzeyD J Tindall

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Citations

May 10, 2005·International Journal of Cancer. Journal International Du Cancer·Andreas WadleChristoph Renner
Jan 16, 2016·American Journal of Respiratory Cell and Molecular Biology·Christina MoulakakisCordula Stamme

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