Clathrin-independent endocytosis, retrograde trafficking, and cell polarity

Current Opinion in Cell Biology
Massiullah Shafaq-ZadahLudger Johannes

Abstract

Several mechanisms allow for cargo internalization into cells within membrane-bound endocytic carriers. How these internalization processes couple to specific pathways of intracellular distribution remains poorly explored. Here, we review uptake reactions that are independent of the conventional clathrin machinery. We discuss how these link to retrograde trafficking from endosomes to the Golgi apparatus and exemplify biological situations in which the polarized secretion capacity of the Golgi apparatus allows for retrograde cargoes to be delivered to specialized areas of the plasma membrane, such as the leading edge of migratory cells or the immunological synapse of immune cells. We also address the evidence that allows to position apicobasal polarity of epithelial cells in this context. The underlying theme is thereby the functional coupling between specific types of endocytosis to intracellular retrograde trafficking for protein cargoes that need to be localized in a highly polarized and dynamic manner to plasmalemmal subdomains.

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Citations

Jan 28, 2021·Micromachines·Liu-Yuan GuanBo Li
Nov 11, 2020·International Journal of Molecular Sciences·Elisabetta MandariniChiara Falciani
Oct 21, 2020·Current Opinion in Cell Biology·Frances M Brodsky, Jennifer L Stow
Feb 23, 2021·Frontiers in Microbiology·Inés RipaRaquel Bello-Morales
Apr 17, 2021·Current Opinion in Cell Biology·Henri-François Renard, Emmanuel Boucrot
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ludger Johannes
Aug 15, 2021·Glycoconjugate Journal·Fulvio ReggioriEeva-Liisa Eskelinen
Aug 27, 2021·Toxins·Anne K KenworthyWayne I Lencer

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Methods Mentioned

BETA
GTPase
GTPases

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