Claudin-1 and claudin-2 differentiate fetal and embryonal components in human hepatoblastoma

Human Pathology
Judit HalászAndrás Kiss

Abstract

Claudins (CLDNs), a family of transmembrane proteins, are major constituents of tight junctions (TJs). They have been shown to be differentially regulated in malignant tumors and play a role in carcinogenesis and progression. We aimed to explain the molecular mechanism underlying the main epithelial components of hepatoblastomas (HBs) based on the composition of TJs. Fourteen formalin-fixed, paraffin-embedded surgical resection specimens were analyzed by immunohistochemistry for CLDN-1, -2, -3, -4, -7; proliferating cell nuclear antigen (PCNA); Ki-67; beta-catenin; cytokeratin-7 (CK-7); and hepatocyte-specific antigen; messenger RNA was isolated for real-time reverse transcriptase polymerase chain reaction analysis of the CLDNs from dissected fetal and embryonal cell types. Significantly increased protein and messenger RNA expression of CLDN-1 and -2 was detected in the fetal compared with the embryonal component. Both cell types displayed negative or weak immunostainings for CLDN-3, -4, and -7. Hepatocyte-specific antigen was dominantly expressed in the fetal component. PCNA and Ki-67 labeling indices were significantly higher in embryonal compared with fetal cells. beta-catenin cytoplasmic/nuclear immunoreaction was frequent,...Continue Reading

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Citations

Sep 22, 2012·BMC Gastroenterology·Klaus MönkemüllerPeter Malfertheiner
Oct 16, 2008·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Zsuzsanna NémethZsuzsa Schaff
Jan 19, 2010·World Journal of Gastroenterology : WJG·Nikki P Lee, John M Luk
Feb 1, 2014·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Victoria Hahn-StrömbergTorbjörn K Nilsson
Apr 17, 2014·Histopathology·Krisztina SchlachterAndrás Kiss
Apr 10, 2007·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Judit MoldvayAndrás Kiss
Jun 27, 2006·Gynecologic Oncology·Gábor SobelCsilla Páska
Apr 8, 2015·Pathology Oncology Research : POR·Boglárka Erdélyi-BelleLászló Homolya
Aug 10, 2013·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Shengmei ZhouLarry Wang
Mar 26, 2008·Laboratory Investigation; a Journal of Technical Methods and Pathology·Maria V BarbolinaM Sharon Stack
Jun 12, 2018·Journal of Pediatric Hematology/oncology·Çiğdem Ö EcevitNur Olgun
Apr 13, 2007·Virchows Archiv : an International Journal of Pathology·Katalin BorkaAndrás Kiss
Sep 20, 2017·EMBO Molecular Medicine·Stefania CrippaEtienne Meylan
Feb 27, 2014·Virchows Archiv : an International Journal of Pathology·Mónika GyugosAndrás Kiss
Apr 9, 2019·Journal of Cellular Biochemistry·Vahid Akbari KordkheyliAbouzar Bagheri
Jul 7, 2009·Pathology Oncology Research : POR·Júlia NémethZsuzsa Schaff
Jun 18, 2020·Reproductive Sciences·Tadahi OkadaTakashi Kojima
Dec 18, 2014·Applied Immunohistochemistry & Molecular Morphology : AIMM·Abderrahman Ouban, Atif Ahmed

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