Claudin-3, claudin-7, and claudin-10 show different distribution patterns during decidualization and trophoblast invasion in mouse and human

Histochemistry and Cell Biology
S SchumannR Grümmer

Abstract

Implantation of the mammalian embryo requires profound endometrial changes for successful pregnancy, including epithelial-mesenchymal transition of the luminal epithelium and stromal-epithelial transition of the stromal cells resulting in decidualization. Claudins (Cldn) determine the variability in tight junction paracellular permeability and may play a role during these epithelial and decidual changes. We here localized Cldn3, Cldn7 and Cldn10 proteins in the different compartments of murine endometrium up to day 8.5 of pregnancy (dpc) as well as in human endometrium and first trimester decidua. In murine estrous endometrium, luminal and glandular epithelium exhibited Cldn3 and Cldn7, whereas Cldn10 was only detectable in glandular epithelium. At 4.5 dpc, Cldn3 protein shifted to an apical localization, whereas Cldn7 vanished in the epithelium of the implantation chamber. At this stage, there was no stromal signal for Cldn3 and Cldn7, but a strong induction of Cldn10 in the primary decidual zone. Cldn3 proteins emerged at 5.5 dpc spreading considerably from 6.5 dpc onward in the endothelial cells of the decidual blood sinusoids and in the decidual cells of the compact antimesometrial region. In addition to Cldn3, Cldn10 was i...Continue Reading

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Citations

Feb 12, 2017·The Journal of Endocrinology·Amanda L PattersonJose M Teixeira
Aug 1, 2018·International Journal of Molecular Sciences·Susanne Grund, Ruth Grümmer
Nov 9, 2018·Human Reproduction Update·Amma Owusu-AkyawSara S Morelli
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Nov 5, 2020·Reproductive Sciences·Enoch Appiah Adu-GyamfiYing-Xiong Wang
Nov 17, 2020·Frontiers in Endocrinology·Sarah WhitbyEvdokia Dimitriadis
Sep 14, 2021·Biology of Reproduction·Jessica S DudleyBronwyn M McAllan

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