Claudins in differential diagnosis between mesothelioma and metastatic adenocarcinoma of the pleura

Journal of Clinical Pathology
Y SoiniP Pääkkö

Abstract

To study the expression of claudins in mesothelioma and metastatic pleural adenocarcinoma. Immunohistochemical staining of claudins 1, 2, 3, 4, 5, and 7 was studied in 35 malignant mesotheliomas and the expression compared with 24 cases of pleural metastatic adenocarcinoma. All cases were also immunostained with calretinin. Claudin 1, 2, 3, 4, 5, and 7 expression was seen in 40%, 80%, 18%, 23%, 14%, and 43% of mesotheliomas, respectively, while the corresponding figures for adenocarcinoma were 100%, 88%, 90%, 100%, 50%, and 92%. Claudins 1, 3, 4, 5, and 7 were significantly less positive in mesothelioma than in metastatic adenocarcinoma, while no difference was observed for claudin 2. Claudins 1, 3, 4, 5, and 7 were also inversely associated with calretinin positivity. Sarcomatoid and biphasic mesothelioma subtypes appeared more negative for these claudins than pure epithelioid subtypes. Claudin expression was not associated with survival of patients with malignant mesotheliomas. The results show that malignant mesotheliomas have a lower expression of claudins 1, 3, 4, 5, and 7 than adenocarcinomas, and their expression could thus be used as an adjunct in differential diagnosis between the two. The difference was most evident f...Continue Reading

References

May 10, 2002·The American Journal of Pathology·Benoit TerrisNicholas R Lemoine
Jul 12, 2002·Kidney International·Jose Luis ReyesLorenza González-Mariscal
Feb 26, 2003·American Journal of Respiratory Cell and Molecular Biology·Fushan WangMichael Koval
Jul 5, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Cecile J FavreDonald M McDonald
Aug 12, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Carolyn B CoyneLarry G Johnson
Nov 5, 2003·The Journal of Pathology·A S AbutailyW R Roche
May 26, 2004·Journal of Cell Science·Kursad Turksen, Tammy-Claire Troy
Dec 25, 2004·Human Pathology·Ylermi Soini

❮ Previous
Next ❯

Citations

Jul 1, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Mirna LechpammerLi J Wang
Dec 1, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Nelson G Ordóñez
Mar 19, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Nelson G Ordóñez
May 19, 2010·Respiratory Research·Riitta KaarteenahoYlermi Soini
May 31, 2011·Respiratory Research·Ylermi Soini
Nov 20, 2012·Respiratory Research·Heta MerikallioYlermi Soini
Jan 25, 2011·Diagnostic Pathology·Tanner L BartholowAnil V Parwani
Oct 16, 2008·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Zsuzsanna NémethZsuzsa Schaff
Apr 14, 2015·Seminars in Cancer Biology·W G JiangD Santini
Oct 14, 2008·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Regine GaetjeManfred Kaufmann
Jan 2, 2009·Ultrastructural Pathology·Ben Davidson
Dec 1, 2015·Annals of Diagnostic Pathology·Nuri YiğitAyhan Özcan
Nov 26, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Heta MerikallioYlermi Soini
May 19, 2007·American Journal of Clinical Pathology·Lilach KleinbergBen Davidson
Jun 19, 2007·Histopathology·F FacchettiA Santin
Oct 4, 2012·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Heta MerikallioYlermi Soini
Aug 20, 2010·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Päivi Väre, Ylermi Soini
Dec 7, 2013·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Elina Pirinen, Ylermi Soini
Jun 16, 2010·Histopathology·Ylermi SoiniVesa Kärjä
May 4, 2015·Annals of Diagnostic Pathology·Siham Chaouche-MazouniPierre Gosset
Dec 29, 2010·Respiratory Physiology & Neurobiology·Alexander G MarkovSalah Amasheh
Feb 23, 2013·Human Pathology·Nelson G Ordóñez
Sep 15, 2016·Pflügers Archiv : European journal of physiology·Makoto OsanaiNorimasa Sawada
Apr 19, 2013·American Journal of Clinical Pathology·Nelson G Ordóñez
Aug 8, 2019·Cytopathology : Official Journal of the British Society for Clinical Cytology·Melissa VojtekPaul W Shield
May 23, 2020·Diagnostic Cytopathology·Kenzo HiroshimaKohzoh Imai
Jun 19, 2013·International Journal of Surgical Pathology·Yoshiki OhtaHidekazu Ota
Apr 10, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Ceyhan UgurluogluNuri Duzgun
Jan 14, 2017·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Inga-Marie SchaeferJason L Hornick
Mar 6, 2008·Archives of Pathology & Laboratory Medicine·Alberto M Marchevsky
Jul 10, 2021·Journal of Cancer Research and Clinical Oncology·Olga P PopovaAlexey A Ivanov

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved