Clavanin A-bioconjugated Fe3 O4 /Silane core-shell nanoparticles for thermal ablation of bacterial biofilms

Colloids and Surfaces. B, Biointerfaces
Kalline L RibeiroCesar A S Andrade

Abstract

The use of central venous catheters (CVC) is highly associated with nosocomial blood infections and its use largely requires a systematic assessment of benefits and risks. Bacterial contamination of these tubes is frequent and may result in development of microbial consortia also known as biofilm. The woven nature of biofilm provides a practical defense against antimicrobial agents, facilitating bacterial dissemination through the patient's body and development of antimicrobial resistance. In this work, the authors describe the modification of CVC tubing by immobilizing Fe3O4-aminosilane core-shell nanoparticles functionalized with antimicrobial peptide clavanin A (clavA) as an antimicrobial prophylactic towards Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Klebsiella pneumoniae. Its anti-biofilm-attachment characteristic relies in clavA natural activity to disrupt the bacterial lipidic membrane. The aminosilane shell prevents iron leaching, which is an important nutrient for bacterial growth. Fe3O4-clavA-modified CVCs showed to decrease Gram-negative bacteria attachment up to 90% when compared to control clean CVC. Additionally, when hyperthermal treatment is triggered for 5 min at 80 °C in a tubing that ...Continue Reading

Citations

Feb 13, 2020·Future Microbiology·Nelson G de Oliveira Júnior, Octávio L Franco
Jul 6, 2019·Frontiers in Bioengineering and Biotechnology·Chen XuAiguo Wu
Feb 2, 2021·Chemical Reviews·Jasmin PortelinhaAlfredo M Angeles-Boza
Jan 25, 2020·Molecular Pharmaceutics·Ailton A Sousa-JuniorAndris F Bakuzis
Jun 13, 2020·Colloids and Surfaces. B, Biointerfaces·Yurena LuengoGorka Salas

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