Cleaning Efficiencies of Three Cleaning Agents on Four Different Surfaces after Contamination by Gemcitabine and 5-fluorouracile

Journal of Occupational and Environmental Hygiene
Antje BöhlandtRudolf Schierl

Abstract

Occupational exposure to antineoplastic drugs has been documented for decades showing widespread contamination in preparation and administration areas. Apart from preventive measures, efficient cleaning of surfaces is indispensable to minimize the exposure risk. The aim of this study was to evaluate the efficiency of three cleaning agents after intentional contamination by gemcitabine (GEM) and 5-fluorouracile (5-FU) on four different surface types usually installed in healthcare settings. Glass, stainless steel, polyvinylchloride (PVC), and laminated wood plates were contaminated with 20 ng/μl GEM and 2 ng/μl 5-FU solutions. Wipe samples were analyzed for drug residues after cleaning with a) distilled water, b) aqueous solution containing sodium dodecyl sulfate (10 mM) and 2-propanol (SDS-2P), and c) Incides N (pre-soaked) alcoholic wipes. Quantification was performed by high-performance liquid chromatography (HPLC) for GEM and gas chromato-graphy-tandem mass spectrometry (GCMS/MS) for 5-FU. Recovery was determined and cleaning efficiency was calculated for each scenario. Mean recoveries were 77-89% for GEM and 24-77% for 5-FU and calculated cleaning efficiencies ranged between 95 and 100% and 89 and 100%, respectively. Residu...Continue Reading

References

Oct 1, 1993·Journal of Pharmaceutical Sciences·J A BenvenutoJ C Theiss
Jan 1, 1997·International Archives of Occupational and Environmental Health·S HanselG Duménil
Apr 1, 1996·Pharmaceutical Development and Technology·J A SheaJ Segretario
Dec 3, 1998·Pharmaceutical Development and Technology·J SegretarioJ A Shea
Aug 24, 1999·Journal of Occupational and Environmental Medicine·B ValanisP Steele
Jun 4, 2002·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Gudrun SchmausSabine Funck
Aug 15, 2002·The Annals of Occupational Hygiene·Olle NygrenArne Friberg
May 14, 2003·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Roberta TurciClaudio Minoia
Nov 7, 2003·The Annals of Occupational Hygiene·H J MasonK Jones
Mar 5, 2005·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Thomas H ConnorRobert Dechristoforo
May 12, 2005·International Archives of Occupational and Environmental Health·Wouter FransmanHans Kromhout
Sep 21, 2006·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Sarah RobertsGraham J Sewell
Nov 14, 2006·Epidemiology·Wouter FransmanDick Heederik
Dec 1, 2006·CA: a Cancer Journal for Clinicians·Thomas H Connor, Melissa A McDiarmid
Dec 21, 2006·Journal of Occupational Health·Jin YoshidaShinji Kumagai
Dec 11, 2007·International Archives of Occupational and Environmental Health·M HedmerB A G Jönsson
Jul 22, 2009·The Annals of Occupational Hygiene·Rudolf SchierlDennis Nowak
Mar 9, 2010·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Rudolf SchierlElke Fischer
Oct 1, 2010·Journal of Occupational and Environmental Medicine·Thomas H ConnorMelissa A McDiarmid
Jul 9, 2011·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Winnie C ChuGeorge Astrakianakis
Apr 25, 2012·International Archives of Occupational and Environmental Health·Laetitia Minh Mai LêEric Caudron
May 15, 2013·Journal of Occupational and Environmental Hygiene·Chun-Yip HonScott Venners
May 17, 2013·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Sandrine Fleury-SouverainPascal Bonnabry
Aug 10, 2013·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Chun-Yip HonGeorge Astrakianakis
Apr 15, 2014·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Hiroshi GohmaShin-Ichi Sugiura

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Citations

Oct 22, 2016·Analytical and Bioanalytical Chemistry·Terence HetzelTorsten C Schmidt
Jun 1, 2017·The Analyst·Nicolas GuichardSandrine Fleury-Souverain
Oct 18, 2018·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Luci A Power, Joseph W Coyne
Feb 23, 2019·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Nicolas SimonSandrine Fleury-Souverain
Feb 26, 2019·Clinical Orthopaedics and Related Research·Jack G GrahamPedro K Beredjiklian
Dec 19, 2019·Annals of Work Exposures and Health·Nicolas SimonSandrine Fleury-Souverain
Apr 14, 2020·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Ophélie PetitPascal Odou
Dec 29, 2020·Journal of Occupational and Environmental Hygiene·Marie PalaminiJean-François Bussières
Mar 20, 2021·Clinical Journal of Oncology Nursing·Seth EisenbergAngela Rodriguez
Oct 29, 2021·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Ginjiro KatoKazuki Akira
Nov 2, 2021·Journal of Occupational and Environmental Hygiene·Monica KåredalMaria Hedmer

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