Clear cell atypical fibroxanthoma - report of a case with review of the literature

Journal of Cutaneous Pathology
Rajmohan Murali, Simon Palfreeman

Abstract

Clear cell atypical fibroxanthoma (CCAFX) is a rare variant of atypical fibroxanthoma (AFX), a pleomorphic dermal tumour associated with a good prognosis. A 67-year-old man presented with a rapidly growing nodule on the ear, which had appeared over a 2-week period. Sections showed an ulcerated nodule composed of pleomorphic spindled and polygonal cells with clear cytoplasm, invested by a delicate vascular stroma, reminiscent of clear cell renal cell carcinoma. Numerous mitotic figures were seen. The tumour cells stained with vimentin, CD68 and CD99 and were cytokeratin-negative. The immunohistochemical and ultrastructural features supported a diagnosis of CCAFX. The diagnosis of CCAFX requires the exclusion of other pleomorphic clear cell tumours that can occur in the skin by using a combination of morphology, immunohistochemistry and electronmicroscopy. Murali R, Palfreeman S. Clear cell atypical fibroxanthoma - report of a case with review of the literature.

References

Apr 1, 1992·American Journal of Clinical Pathology·C K MaA M Gown
Jun 1, 1988·Journal of Cutaneous Pathology·R E Cohen, M T Zaim
Oct 1, 1987·The American Journal of Dermatopathology·S Tamada, A B Ackerman
Oct 1, 1987·The Journal of Dermatologic Surgery and Oncology·J W PattersonW M Kramer
Jul 1, 1993·Journal of the American Academy of Dermatology·W P SuB W Scheithauer
Aug 1, 1993·Journal of Cutaneous Pathology·R J BarrD F Fretzin
Dec 1, 1993·The American Journal of Surgical Pathology·T A LongacreR V Rouse
Apr 1, 1996·The American Journal of Surgical Pathology·B W ZelgerH Kutzner
Jan 1, 1997·Histopathology·B Wambacher-GasserH Steiner
Dec 3, 1999·Histopathology·R Lázaro-SantanderJ M Vera-Román
Jan 16, 2002·American Journal of Clinical Pathology·Carlos MonteagudoAntonio Llombart-Bosch
Jul 24, 2002·Journal of Cutaneous Pathology·A Neil CrowsonTamara Hill
Sep 3, 2003·Journal of Cutaneous Pathology·J Fernando Val-BernalJorge Cuevas

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Citations

Jan 24, 2008·The American Journal of Dermatopathology·Rahel A MathewMichael B Morgan
Jun 2, 2010·The American Journal of Dermatopathology·Saul OffmanNoreen Walsh
Apr 20, 2012·The American Journal of Dermatopathology·Asok Biswas, Meera Mahalingam
Jun 30, 2011·The American Journal of Dermatopathology·Jose Aneiros-FernandezJose Aneiros-Cachaza
Jan 29, 2011·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Luciano J Iorizzo, Marc D Brown
May 30, 2009·Journal of Cutaneous Pathology·Jinah Kim, Jennifer M McNiff
Dec 17, 2008·Dermatologic Therapy·Steven Marcet
Mar 13, 2008·Journal of Cutaneous Pathology·Alde Carlo P GavinoNasir A Bakshi
Oct 1, 2011·Journal of Cutaneous Pathology·Timothy H McCalmont
Sep 22, 2009·Journal of Cutaneous Pathology·Catherine M StefanatoJ Eduardo Calonje
Nov 20, 2014·Journal of Cutaneous Pathology·Solomon S LeePaul B Googe
Mar 10, 2016·Journal of Cutaneous Pathology·Catherine M NguyenDavid Cassarino
Dec 8, 2009·Ophthalmic Plastic and Reconstructive Surgery·Usha R KimAkash D Shah
Jan 9, 2010·Histopathology·Bostjan Luzar, Eduardo Calonje
Apr 7, 2015·Advances in Anatomic Pathology·Nancy ChengDavid S Cassarino
Mar 10, 2016·The American Journal of Dermatopathology·Cristina N Brau JavierJulio E Sánchez
Feb 11, 2014·Advances in Anatomic Pathology·Thomas Brenn
Oct 26, 2016·Journal of Cutaneous Pathology·Jose L Ramírez-BellverLuis Requena
Oct 1, 2007·The Canadian Journal of Plastic Surgery = Journal Canadien De Chirurgie Plastique·Mark M MelendezSu-I Daniel Huang

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