Clear-cell carcinoma: an ultrastructural study of 57 tumors from various sites

Ultrastructural Pathology
T J KwonB Mackay

Abstract

Clear-cell carcinoma is a convenient and frequently used descriptive term for a malignant epithelial neoplasm that is entirely or largely composed of cells with optically clear cytoplasm in hematoxylin-eosin-stained sections. Transmission electron microscopy was performed on 57 tumors from various sites to investigate the fine structural basis for the clarity of the cytoplasm. The clear appearance resulted from the presence of one or several of the following features, as the sole or predominant cause or in combination: glycogen, lipid droplets, mucin vacuoles or diffuse mucosubstances, dilated cisternae, swollen or unusually large mitochondria, large solitary membrane-limited vacuoles or numerous smaller vacuoles, intracytoplasmic lumens, expanded intercellular spaces, cytoplasmic pseudoinclusions, and a paucity of organelles. Degenerative changes contributed to the clear appearance by inducing swelling of mitochondria and creating lucent cytosol. The factors responsible for the clear cytoplasm were not always consistent with regard to tumor type or site of origin, but glycogen was the commonest reason among the 57 tumors studied and the principal cause in tumors of the female genital tract, skin, and salivary glands, while ren...Continue Reading

References

Nov 1, 1990·Histopathology·R H SimpsonA V Babajews
Aug 1, 1991·Oral Surgery, Oral Medicine, and Oral Pathology·I OgawaE Vuhahula
Jun 1, 1988·Journal of Cutaneous Pathology·R E Cohen, M T Zaim
Dec 1, 1988·Journal of Cutaneous Pathology·G F Oliver, R K Winkelmann
Jan 1, 1987·Ultrastructural Pathology·B MackayJ L Bennington
Feb 1, 1988·Journal of Cutaneous Pathology·M A Barnadas, R G Freeman
Jan 1, 1987·Ultrastructural Pathology·M T HullJ N Eble
Aug 1, 1985·Journal of Clinical Pathology·C Edwards, A Carlile
Oct 1, 1985·The American Journal of Surgical Pathology·M L CarcangiuJ Rosai
Apr 1, 1983·American Journal of Clinical Pathology·L A GuardaM L Ibanez
Oct 1, 1980·The American Journal of Surgical Pathology·G R DickersinS B Smith
Aug 1, 1995·The American Journal of Surgical Pathology·M M HayesM A Ashton
Feb 1, 1995·Histopathology·M O'Donnell, A I al-Nafussi
Nov 1, 1994·Journal of Surgical Oncology·W V McDermott, U Khettry
Oct 1, 1993·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·T YamamatoK Mitsui
Jan 1, 1994·Ultrastructural Pathology·B MackayN G Ordonez
Aug 1, 1993·Journal of Cutaneous Pathology·R J BarrD F Fretzin
May 1, 1993·Ultrastructural Pathology·W A MouradD A Swanson
Sep 9, 1993·International Journal of Cancer. Journal International Du Cancer·E van den BergB de Jong
Feb 1, 1993·Histopathology·N G OrdóñezJ Duncan

❮ Previous
Next ❯

Citations

May 26, 2009·Actas dermo-sifiliográficas·R Corbalán-VélezF J Carapeto
Aug 26, 2009·The International Journal of Biochemistry & Cell Biology·Gabriel Arismendi-Morillo
Sep 1, 2016·Diagnostic Cytopathology·Jefree J Schulte, Ricardo R Lastra
Nov 28, 2017·Nature Communications·Weinan DuScott M Welford
Feb 1, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·A Neil CrowsonMartin C Mihm
Aug 24, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·L A MurakataU C Nzeako
Dec 17, 2003·Journal of Cutaneous Pathology·Carlos Diaz-CascajoJesus Bastida-Inarrea
Aug 2, 2017·Annals of Dermatology·Dong Yoon LeeTae Young Yoon
May 12, 2019·Diagnostic Pathology·Yuzo OyamaTsutomu Daa
Apr 24, 2019·World Journal of Gastroenterology : WJG·Tony El JabbourHwajeong Lee
Jan 16, 2021·Virchows Archiv : an International Journal of Pathology·José-Antonio Ortiz-ReyCarolina Gómez-de María
Aug 25, 2001·Archives of Pathology & Laboratory Medicine·W Cheuk, J K Chan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adenocarcinoma, Clear Cell

Clear Cell Adenocarcinoma is a tumor that arises in the female genital tract and is characterized by cells that appear clear under the microscope. Discover the latest research here.