Clear cell carcinoma of the endometrium causing paraneoplastic retinopathy: case report and review of the literature.

Case Reports in Obstetrics and Gynecology
Paulina CybulskaMarcus Q Bernardini

Abstract

We reviewed the literature for cases in which gynecologic malignancies caused paraneoplastic retinopathy and ultimately led to blindness. Twenty-eight cases were derived from the literature, and one unique case is described from our institution. Of these 28 cases, 14 patients were diagnosed with endometrial cancer, 7 with ovarian cancer, 5 with cervical cancer, 1 fallopian tube cancer and 1 with concomitant endometrial and ovarian cancers. The average age of patients at the time of diagnosis was 64 years (range, 35-89 years). Typically, ocular manifestations antedate symptoms of the underlying carcinoma by 3-12 months. Information regarding the interval from visual symptoms to time of death is limited, but ranges from several months to several years. Our report is the first to document a clear cell carcinoma of the endometrium causing paraneoplastic retinopathy and is the first to review all gynecologic malignancies associated with visual paraneoplastic syndromes.

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Citations

Sep 1, 2014·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Kiran TurakaChristin Sylvester
Feb 11, 2016·Clinical Case Reports·Benjamin WeixlerChristian Andreas Nebiker

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Methods Mentioned

BETA
hysterectomy

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