PMID: 589565Dec 1, 1977

Clear cell carcinoma of the ovary: light and electron microscopic studies

Cancer
K OhkawaE Ishikawa

Abstract

Twelve cases of ovarian clear cell carcinoma were studied histologically. Four cases were examined electron microscopically and compared with other conditions. Five tumors were directly connected with ovarian endometriosis. They were histologically classified into a tubular type with hobnail cells and a solid type without tubular pattern or hobnail cells. Electron microscopic figures of the tumor cells are identical having large nuclei, abundant glycogen, lamellated RER, few lipid droplets, and sparse but well-developed microvilli. The basophilic dark cells frequently encountered in the tubular type are morphologically quite similar to clear cells excepting for sparsity of glycogen and lipid droplets. Alveolar arrangement of 6 to 10 tubular structures (honeycomb structure) resembling alveolate structure seen in late secretory endometrium was found in tumor cells of one case. Ultrastructural feature of clear cell carcinoma closely resemble those of Arias-Stella endometrium and clear cell carcinoma of endocervix suggesting their Muellerian origin.

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Citations

Dec 1, 1979·Virchows Archiv. A, Pathological Anatomy and Histology·C Y Genton
Nov 4, 2006·Journal of Computer Assisted Tomography·Hyuck Jae ChoiSang-Yoon Park
Sep 1, 1987·Acta Pathologica Japonica·N KanaiT Tanaka
Feb 1, 1992·Pathology, Research and Practice·M HelleT Wahlström
May 29, 2007·Gynecologic Oncology·Sunyoung LeeSamuel C Mok
Mar 1, 1989·Gynecologic Oncology·A W KennedyK D Webster
Mar 7, 2006·Gynecologic Oncology·Dimitrios PectasidesMeletios A Dimopoulos
May 9, 2015·Future Oncology·Ioannis Gounaris, James D Brenton
Sep 19, 1998·Gynecologic Oncology·K BehbakhtS C Rubin
Nov 12, 2014·Annual Review of Pathology·Julien Masliah-PlanchonOlivier Delattre
Mar 5, 2009·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·P J TimmersJ B Trimbos
May 2, 2009·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Hiroshi KobayashiHidekazu Oi
Nov 18, 2006·The Oncologist·Dimitrios PectasidesTheofanis Economopoulos
Nov 2, 2013·Oncology Letters·Chiharu UekuriHiroshi Kobayashi
Feb 8, 2020·Cell Death & Disease·André L S CruzPatricia T Bozza

Related Concepts

Carcinoma, Cribriform
Cervix Carcinoma
Endometrioma
Endometrium
Glycogen
Malignant Neoplasm of Kidney
Mesonephroma
Electron Microscopy
Neoplasms, Multiple Primary
Ovarian Neoplasm

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