Abstract
The aim of this study was to summarize the clinical and pathological characteristics and to conduct prognosis analysis of patients who were diagnosed with clear cell carcinoma of the uterine cervix (CCCUC) and without a history of exposure to diethylstilbestrol. We performed a retrospective review of all the patients with CCCUC who were diagnosed and treated at Zhejiang Cancer Hospital between 1998 and 2014. Charts were reviewed for clinical and pathological characteristics, and prognosis analysis was conducted. A total of 47 patients were included. Median age was 52 years. No patient had a history of exposure to diethylstilbestrol. The International Federation of Gynecology and Obstetrics stage distribution was 55.3% (n = 26) stage I, 40.4% (n = 19) stage II, 2.1% (n = 1) stage III, and 2.1% (n = 1) stage IV. Forty-two patients (89.4%) underwent radical hysterectomy and pelvic lymphadenectomy. Pathological examination revealed deep cervical stromal invasion (greater than two thirds) in 20 patients (48.4%), pelvic lymph node (PLN) metastasis in 10 patients (23.8%), lymphovascular space involvement in 9 patients (21.4%), and ovarian metastasis in 1 patient (2.4%). Advanced tumor stage (IIB-IV), larger tumor size (>4 cm), and PLN...Continue Reading
References
Apr 15, 1971·The New England Journal of Medicine·A L HerbstD C Poskanzer
Jun 1, 1997·Cancer·A HanselaarJ Bernhelm
Jul 27, 1999·Gynecologic Oncology·N NatsumeK Tanaka
Feb 24, 2000·Gynecologic Oncology·O ReichR Winter
Aug 25, 2001·Gynecologic Oncology·T NakanishiK Kuzuya
Sep 5, 2001·Gynecologic Oncology·R YamamotoS Fujimoto
Dec 10, 2003·International Journal of Clinical Oncology·Hiroyuki SekiToshimasa Uekusa
Nov 23, 2005·Gynecologic Oncology·Muneaki ShimadaNaoki Terakawa
Feb 21, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·F LandoniUNKNOWN Cooperative Task Force
Feb 28, 2008·European Journal of Cancer Care·M-T LiuT-H Chen
Apr 9, 2008·Gynecologic Oncology·M Bijoy ThomasSean C Dowdy
May 28, 2009·Journal of Gynecologic Oncology·Min-Jeong KimSoon-Beom Kang
May 7, 2010·Japanese Journal of Clinical Oncology·Yuzuru NiibeKazushige Hayakawa
Jan 24, 2012·Gynecologic Oncology·Vijaya GalicJason D Wright
Mar 1, 2012·International Journal of Radiation Oncology, Biology, Physics·Yi-Ting HuangJi-Hong Hong
Jan 29, 2014·OncoTargets and Therapy·Xiang JiangLing-Ya Pan
Feb 4, 2014·Gynecologic Oncology·Jae Myoung NohSeung Jae Huh
Mar 22, 2014·Molecular and Clinical Oncology·Muneaki ShimadaJunzo Kigawa
May 3, 2014·Gynecologic Oncology·Raquel Dávila FajardoLukas J A Stalpers
Oct 13, 2015·The American Journal of Surgical Pathology·Yevgeniy S KaramurzinKay J Park
Dec 15, 2015·PloS One·Jung-Yun LeeYoung-Joo Won
Citations
Jul 6, 2018·Endocrine-related Cancer·Andrea NicoliniAngelo Carpi
Aug 25, 2018·Mikrochimica Acta·Shuyue RenZhixian Gao
May 3, 2019·Obstetrics and Gynecology International·Dongying WangTianmin Xu
Apr 24, 2020·Journal of Immunology Research·Liju ZongYang Xiang
Oct 12, 2018·Endocrine-related Cancer·Andrea NicoliniAngelo Carpi
Dec 8, 2020·Frontiers in Oncology·Zhimin LiuJihong Liu