Clear cell colitis: a form of microscopic colitis in children

World Journal of Gastroenterology : WJG
Jan Józefczuk, Bogdan Marian Woźniewicz

Abstract

To describe a new clinical and pathological subtype of microscopic colitis in children. A selected group of children with abdominal pain, constipation and/or diarrhoea showing discrete or no macroscopic abnormalities on endoscopy was described. Multiple biopsies of colon showed large mononuclear clear cells in lamina propria of mucous membrane provided that good quality histological sections were performed and observed under a higher magnification. Otherwise, they could be misinterpreted as artefacts. Their presence in routine histology might suggest a systemic storage disease (Whipple's disease), and neuronal intestine dysplasia. Using immunohistochemical staining and electron microscopy we confirmed their origin from CD68 positive mononuclear macrophages. The presence of large clear cells is a constant microscopic feature. Failure of transient large bowel stationary macrophages plays a role in the pathogenesis of this benign microscopic clear cell colitis, sometimes coexisting with allergy.

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Citations

Sep 5, 2009·Digestive Diseases and Sciences·Wael El-MataryBrendan Diederichs
Oct 13, 2011·ISRN Gastroenterology·Jan Józefczuk, Bogdan Marian Woźniewicz
Apr 4, 2013·Journal of Pediatric Gastroenterology and Nutrition·Prashant SinghShinjini Bhatnagar
Aug 10, 2021·Annals of Medicine·Istvan FedorZsolt Barta

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