PMID: 8604817Apr 1, 1996Paper

Clear cell dermatofibroma. Case report of an unusual fibrohistiocytic lesion

The American Journal of Surgical Pathology
B W ZelgerH Kutzner

Abstract

A case of clear cell dermatofibroma is presented. Clinically, a 41-year-old woman exhibited a hard brown nodule on her instep that was assumed to be a dermatofibroma. Histologically, more than 90% of the lesion was composed of clear cells. Epidermal hyperplasia and a storiform arrangement of spindle cells and sclerotic collagen in some foci at the periphery of the lesion indicated the fibrohistiocytic origin. Moreover, prominent vascularity and some bizarre giant cells in the lower part of the lesion were reminiscent of multinucleate cell angiohistiocytoma. Of a broad panel of antibodies, the lesion was positive only for Factor XIIIa (and vimentin). Ultrastructurally, clear-cell changes corresponded to a mostly translucent cytoplasm, focally with some endoplasmic reticulum and prominent lysosomal structures. A review of 1,496 dermatofibromas seen during the last 15 years at our institute revealed 12 cases (1%) with similar clear-cell changes in a minor part of the infiltrate (less than 10%). The differential diagnosis includes metastases of renal-cell carcinoma, which exhibit more atypia and mitoses and are positive for epithelial cell markers; clear-cell sarcoma, a lesion of tendons or aponeurosis with some moderate cytoplasmi...Continue Reading

References

Dec 1, 1991·Journal of the American Academy of Dermatology·M BeerC Schmoeckel
Dec 1, 1990·The American Journal of Surgical Pathology·H Kamino, M Jacobson
Feb 1, 1989·The British Journal of Dermatology·E W JonesN P Smith
Oct 1, 1987·The American Journal of Dermatopathology·S Tamada, A B Ackerman
Dec 1, 1986·The American Journal of Dermatopathology·W H Leyva, D J Santa Cruz
Dec 1, 1986·Journal of Cutaneous Pathology·V S Schwob, D J Santa Cruz
Apr 15, 1981·Cancer·D J Santa Cruz, M Kyriakos
Oct 1, 1983·Journal of Cutaneous Pathology·H FukamizuH Tagami
Jun 1, 1995·Histopathology·B W ZelgerB G Zelger
Apr 1, 1995·Journal of Cutaneous Pathology·J LeeK Rothman
Dec 1, 1994·The American Journal of Dermatopathology·B ZelgerE Wilson-Jones
Jul 1, 1994·The American Journal of Surgical Pathology·B ZelgerK W Schmid
Feb 1, 1994·The American Journal of Surgical Pathology·B ZelgerE Wilson-Jones
Apr 1, 1995·The American Journal of Dermatopathology·B W ZelgerK W Schmid

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Citations

Oct 1, 1996·The American Journal of Dermatopathology·B W ZelgerR Cerio
Dec 10, 1997·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·B G ZelgerB Zelger
Apr 7, 2007·The American Journal of Dermatopathology·Tien Anh TranJ Andrew Carlson
Oct 26, 2007·Pediatric Dermatology·Susan E StinehelferDean S Morrell
Jan 22, 2009·The American Journal of Dermatopathology·M C Garrido-RuizJosé L Rodriguez Peralto
Apr 20, 2012·The American Journal of Dermatopathology·Asok Biswas, Meera Mahalingam
Mar 29, 2016·World Journal of Methodology·Mar Llamas-VelascoThomas Mentzel
May 25, 2002·Journal of Cutaneous Pathology·Friedrich BreierBernhard W H Zelger
Apr 28, 2006·Journal of Cutaneous Pathology·Rajmohan Murali, Simon Palfreeman
Jun 18, 2014·Anais Brasileiros De Dermatologia·João Vítor Pina AlvesElvira Augusta Felgueira Leonardo Fernandes Bártolo
Apr 7, 2015·Advances in Anatomic Pathology·Nancy ChengDavid S Cassarino
Sep 15, 2004·The American Journal of Dermatopathology·Michael WilkBernhard Zelger
Feb 1, 1997·The American Journal of Surgical Pathology·B ZelgerE Egarter-Vigl
Dec 1, 1996·Journal of Cutaneous Pathology·J F Val-Bernal, C Mira
Feb 1, 1997·The American Journal of Surgical Pathology·C PatiesG L Taccagni
May 7, 1999·Histopathology·B G ZelgerB Zelger
Oct 21, 2004·International Journal of Surgical Pathology·Bernhard ZelgerWalter H C Burgdorf
Feb 19, 2008·The American Journal of Surgical Pathology·Bernadette LieglChristopher D M Fletcher
Mar 3, 2015·Journal of Cutaneous Pathology·Majid Zeidi, Jeffrey P North
Aug 9, 2020·Journal of Cutaneous Pathology·Sabrina Lichon BennettDiana Bolotin
Jun 1, 1997·The American Journal of Surgical Pathology·B Zelger
May 20, 1998·The American Journal of Surgical Pathology·T T KuoH L Chan
Apr 3, 1999·Seminars in Cutaneous Medicine and Surgery·M R WickP E Swanson
Jul 24, 2002·Journal of Cutaneous Pathology·A Neil CrowsonTamara Hill
Jul 26, 2002·Journal of Cutaneous Pathology·Pei HuiArchibald S Perkins
Jul 14, 2004·The American Journal of Dermatopathology·Alexander J F Lazar, Christopher D M Fletcher
Mar 13, 2008·Journal of Cutaneous Pathology·Alde Carlo P GavinoNasir A Bakshi
Apr 1, 1997·The American Journal of Dermatopathology·H P SoyerH Kerl
Aug 20, 2021·The American Journal of Dermatopathology·Pedro ZaballosLuis Requena

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