Clear-cell myoepithelial carcinoma of the salivary glands: a clinicopathologic, immunohistochemical, and ultrastructural study of two cases involving the submandibular gland with review of the literature

Pathology, Research and Practice
Nunzia Simona LositoMichele Bisceglia

Abstract

Myoepithelial carcinoma (MC) is an uncommon neoplasm of the salivary glands, and cases of the clear-cell (CC) variant are extremely rare. Two cases of MC of the CC variant arising in the left submandibular gland are described herein. Both cases, which involved elderly women, almost exclusively consisted of large glycogen-rich CCs. Both cases were immunopositive for several epithelial and myoepithelial markers, and electron microscopy (EM) demonstrated hybrid epithelial and myoid differentiation in both. Case 1 arose in a pre-existing pleomorphic adenoma ("ex mixed tumor MC"), while Case 2 was a "de novo MC". CC-MC is an aggressive tumor with frequent recurrence, lymph node, and systemic metastases. A total of 14 cases of this type of neoplasm have been reported so far in the salivary glands, two arising from the submandibular gland. To date, only four cases have been studied using EM. The cases of CC-MC presented here are the third and fourth ones, respectively, originating from the submandibular glands, and the first two cases arising from this location, in which EM investigation succeeded in demonstrating myoepithelial differentiation. CC-MC needs to be distinguished from diverse primary and secondary CC neoplasms.

References

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Citations

May 26, 2009·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Kyoko YamashitaKenichiro Murakami
Jun 26, 2014·Contemporary Clinical Dentistry·Jeevan LataVimal Chand
Sep 16, 2011·World Journal of Surgical Oncology·Juan RenShiwen Jiang
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Jul 2, 2010·Journal of Cutaneous Pathology·Bryan Leigh GammonThomas Lee Cibull
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Feb 1, 2015·Annals of Surgical Oncology·Yu-Xiong SuMichael E Kupferman
Jul 8, 2008·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Flávia Caló Aquino XavierSuzana Cantanhede Orsini Machado de Sousa
Apr 5, 2015·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Ruta GuptaJonathan R Clark
Oct 29, 2015·Acta Radiologica·Jianhui DingTongzhen Chen
Feb 27, 2007·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Hiroyuki SuzukiKenji Hashimoto
Feb 7, 2019·Case Reports in Pathology·Jiayun FangDaniel Kleven

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