Clear cell odontogenic carcinoma, diagnostic difficulties. A case report

Journal of Stomatology, Oral and Maxillofacial Surgery
U OrdioniJ-H Catherine

Abstract

Clear cell odontogenic carcinoma (COCC) is a rare tumor described by Hansen et al. in 1985. The clinical and radiological manifestations are multiple and the diagnosis is histological. A 64-year-old patient consulted us for a right mandibular osteolytic lesion associated to a homolateral labial hypoesthesia. A biopsy was performed under local anesthesia. Histology was consistent with a metastatic lesion of clear kidney cell carcinoma, COCC, or odontogenic squamous tumor. Additional tests eliminated a metastatic lesion. A wide excision of the lesion by hemi-mandibulectomy associated with lymph node dissection and reconstruction by a fibula osteoseptocutaneous flap was performed. Presence of a fission of the EWSR1 gene on the histological examination of the surgical specimen made the diagnosis of COCC. Our observation illustrates the difficulty of diagnosing COCC. The new contribution of the cytogenetic techniques such as FISH-type techniques makes possible the improvement of the diagnosis.

References

Nov 1, 1985·Head & Neck Surgery·L S HansenN B Powell
Aug 5, 1998·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·H YamamotoT Tagawa
Jul 8, 2008·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Flávia Caló Aquino XavierSuzana Cantanhede Orsini Machado de Sousa
Dec 17, 2008·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·André ChaineChloé Bertolus
Jul 13, 2014·International Journal of Oral and Maxillofacial Surgery·R KrishnamoorthyM Batstone
Sep 24, 2014·Journal of the Korean Association of Oral and Maxillofacial Surgeons·Minkyu KimWoong Nam
May 23, 2015·Head and Neck Pathology·Daniel Thomas GinatNicole A Cipriani
Aug 4, 2015·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Adriano Mota LoyolaRicardo Santiago Gomez
Sep 26, 2015·World Journal of Surgical Oncology·Ik Jae KwonSuk Keun Lee

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Citations

Sep 5, 2019·Pathology Oncology Research : POR·Liu LiuXi-Hu Yang
Sep 21, 2021·Oral and Maxillofacial Surgery·Erasmo Bernardo MarinhoFabricio Bitu Sousa
Oct 8, 2021·Head and Neck Pathology·Alberto Jose Peraza LabradorJohn M Wright

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