PMID: 29469771Feb 23, 2018Paper

Clear cell papulosis: report and review

Dermatology Online Journal
Caitlin M SeykoraPatrick J Brown J Brown

Abstract

A 12-month-old boy presented with three months of asymptomatic hypopigmented flat-topped papules on the suprapubic skin and lower abdomen. Emollients and topical steroids offered no improvementand the patient was referred to the dermatology department. Shave biopsy revealed a papillated epidermis with scattered solitary mononuclearclear cells at all levels of the epidermis and an overlying basket weave orthokeratosis. The cells were epithelioid with increased amphophilic cytoplasm. Immunohistochemical staining was positive for CK7,CEA, and CAM5.2 and negative for S100, CD1a, and Mart-1. These findings were consistent with clear cell papulosis. No treatment was recommended as these lesions were asymptomatic. However, yearlyfollow up was recommended given the resemblance of these cells to those of Paget disease. Review of the literature demonstrates a total of 31 biopsy confirmed cases with AE1, CEA, and EMA positivity and S100negativity as the most consistent staining properties. A recent retrospective review of 19 cases documents long term follow-up of at least six years and up to 21 years. The results suggested a tendency toward selfresolution and an absence of malignant progression, supporting the benign nature of these lesions.

Related Concepts

Related Feeds

Adenocarcinoma, Clear Cell

Clear Cell Adenocarcinoma is a tumor that arises in the female genital tract and is characterized by cells that appear clear under the microscope. Discover the latest research here.

Related Papers

Dermatology Online Journal
Rachel Farley-LoftusJulie V Schaffer
Dermatology : International Journal for Clinical and Investigative Dermatology
R GianottiC Gelmetti
Annals of the Academy of Medicine, Singapore
Dingyuan WangYoke Chin Giam
Archives of Pathology & Laboratory Medicine
Sujith Prasad Wanniarachchi KumarasingheMarian Priyanthi Kumarasinghe
© 2022 Meta ULC. All rights reserved