Clear cell sarcoma of the kidney. A study of 13 cases

Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie
M El KababriF Msefer-Alaoui

Abstract

Clear cell sarcoma of the kidney (CCSK) also called a "bone-metastasizing renal tumor of childhood" is the second common pediatric renal neoplasm. This tumor is associated with a higher rate of relapse and a wider distribution of metastases than Wilms' tumor. We have reviewed records of 13 cases of CCSK among 277 renal tumors (5%) diagnosed at the children's hospital of Rabat between 1990 and 2002. The median age at diagnosis was 14 months (5 months-9 years). The male to female ratio was 5.5:1.00. Abdominal mass, usually the first physical finding, was associated with hematuria in four cases. No congenital malformation syndrome or familial Wilms' tumor were observed. Imaging studies found out seven right and six left intrarenal processes. Preoperative chemotherapy was given according to the SIOP9, SIOP93-01 and GFAOP 98 protocols. Twelve of 13 children underwent nephrectomy. Tumor measurements varied through 450-3450 g and 7-26 cm. The classic morphologic pattern was seen in nine cases (69%). The distribution local stage was I: three cases; II: three cases; III: six cases; IV: one case. Postoperative chemotherapy and radiotherapy (21 600-30 600 cGy) was done in 10 cases. With a median follow up of 44 months, four patients showe...Continue Reading

Citations

Apr 20, 2005·Virchows Archiv : an International Journal of Pathology·Noelyn Anne Hung
Jan 18, 2007·Pediatric Blood & Cancer·Vlad C RadulescuJeffrey S Dome
Jul 25, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R FurtwänglerM M van den Heuvel-Eibrink
Jun 10, 2008·Annales de pathologie·Samia Hannachi SassiKhaled Ben Romdhane
Nov 19, 2019·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Wai Chin Chong, Jason E Cain

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