Clear cell tumor of the lung could be aggressive: a case report and review of the literature

Journal of Cardiothoracic Surgery
leilei shenLianbin ZHAN

Abstract

Clear cell tumors of the lung (CCTLs) are rare and mostly benign pulmonary neoplasms arising from perivascular epithelioid cells. Only approximately 100 cases have been reported, and half of them were in China. Limited details about CCTLs often cause diagnostic or therapeutic problems. We describe a case of a 28-year-old woman with multiple gradually replicating and enlarging nodules in the left lower lobe. The patient underwent fine-needle aspiration biopsy and was diagnosed with CCTL. A left lower lobectomy and mediastinal lymph node dissection were performed. The gradual changes in size (1.4 cm to 2.8 cm) and quantity (10 to 49) of the CCTLs in this case were the biggest differences from previously reported cases. CCTLs are very uncommon and mostly benign PEComatous tumors with no specific morphologic features. We present a case of CCTL with multiplicity and rapid growth, which may indicate its aggressive nature. The accumulation of similar cases will help clarify the exact nature and improve our understanding of the disease.

References

Mar 24, 2004·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Alfredo N C SantanaTeresa Y Takagaki
Jun 14, 2006·Journal of Pediatric Surgery·Magdalena Gora-GebkaKazimierz Jaskiewicz
Jul 29, 2006·Pathology International·Yoshin AdachiKazuhiko Hayashi
Dec 21, 2006·International Journal of Clinical Oncology·Toshiki HirataSachiko Minamiguchi
Dec 23, 2006·The Annals of Thoracic Surgery·Alpha M KavunkalVijit Koshy Cherian
Aug 3, 2007·Interactive Cardiovascular and Thoracic Surgery·Nikolaos ZarbisHubert Schelzig
Jan 9, 2008·Diagnostic Cytopathology·Maria Luisa Policarpio-NicolasKristen Atkins
Nov 26, 2009·The Annals of Thoracic Surgery·Serdar SenFiruzan Kacar
May 25, 2010·The Annals of Thoracic Surgery·Bingqiang HanNan Song
Jan 25, 2011·The Annals of Thoracic Surgery·Alexandros KalkanisKostas Tsintiris
Oct 3, 2013·World Journal of Surgical Oncology·Guang-xian WangLi Wen
Aug 21, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·William D TravisUNKNOWN WHO Panel

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Methods Mentioned

BETA
biopsy
dissection
SMA
surgical resection

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