Clear genetic distinctiveness between human- and pig-derived Trichuris based on analyses of mitochondrial datasets.

PLoS Neglected Tropical Diseases
Guo-Hua LiuXing-Quan Zhu

Abstract

The whipworm, Trichuris trichiura, causes trichuriasis in ∼600 million people worldwide, mainly in developing countries. Whipworms also infect other animal hosts, including pigs (T. suis), dogs (T. vulpis) and non-human primates, and cause disease in these hosts, which is similar to trichuriasis of humans. Although Trichuris species are considered to be host specific, there has been considerable controversy, over the years, as to whether T. trichiura and T. suis are the same or distinct species. Here, we characterised the entire mitochondrial genomes of human-derived Trichuris and pig-derived Trichuris, compared them and then tested the hypothesis that the parasites from these two host species are genetically distinct in a phylogenetic analysis of the sequence data. Taken together, the findings support the proposal that T. trichiura and T. suis are separate species, consistent with previous data for nuclear ribosomal DNA. Using molecular analytical tools, employing genetic markers defined herein, future work should conduct large-scale studies to establish whether T. trichiura is found in pigs and T. suis in humans in endemic regions.

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Citations

Apr 9, 2013·The Journal of Parasitology·Alexis RibasJoëlle Goüy de Bellocq
Jan 24, 2016·Parasites & Vectors·Mohamed B F HawashPeter Nejsum
Sep 6, 2015·Parasitology Research·Rocío CallejónSteven A Nadler
May 10, 2012·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Jia ChenXing-Quan Zhu
Aug 29, 2012·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Guo-Hua LiuXing-Quan Zhu
Jun 13, 2015·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Serena CavalleroFederica Berrilli
May 29, 2012·Mitochondrial DNA·Guo-Hua LiuXing-Quan Zhu
Aug 8, 2013·Veterinary Parasitology·Lisa GuardoneAlexander Mathis
Apr 11, 2017·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Rocío CallejónCristina Cutillas
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Datasets Mentioned

BETA
AM993026
GU385218
GU070737

Methods Mentioned

BETA
PCR
electrophoresis

Software Mentioned

Tree View
tRNAscan
Clustal X
MrBayes
SE
PhyML
MacVector
PAUP

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