Clearance of 14-3-3 protein from cerebrospinal fluid heralds the resolution of bacterial meningitis

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Stefano BonoraGiovanni Di Perri

Abstract

The 14-3-3 protein, a cerebrospinal fluid (CSF) marker of neuronal damage that was recently adopted for the diagnosis of Creutzfeldt-Jakob disease, is also found in the CSF of patients with a variety of neurological disorders. We prospectively studied 12 consecutive patients with purulent bacterial meningitis and found that 14-3-3 protein was detected in all patients at admission to the hospital. All patients who recovered cleared 14-3-3 protein from the CSF before discharge from the hospital (this was the first CSF marker to clear), whereas those who died never cleared the protein.

References

Sep 11, 1992·The Pediatric Infectious Disease Journal·R D FeiginJ O Klein
Apr 1, 1992·Clinical Microbiology Reviews·L D Gray, D P Fedorko
Sep 26, 1996·The New England Journal of Medicine·G HsichM G Harrington

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Citations

Feb 21, 2008·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·W N ChangH C Wang
Jan 5, 2008·Neurological Research·Axel Petzold
Apr 5, 2005·Journal of Neuropathology and Experimental Neurology·Kristi L HelkeJoseph L Mankowski

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